{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T12:30:49Z","timestamp":1777984249697,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Asthma is a chronic inflammatory disease of the respiratory system characterized by wheezing, shortness of breath, and chest tightness. Although effective medications are available to control symptoms and prevent exacerbations, optimal outcomes depend largely on adherence to evidence-based treatment guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study aimed to evaluate prescriber adherence to the Global Initiative for Asthma (GINA) guidelines, assess its impact on asthma symptom control, and identify challenges and barriers influencing guideline adherence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A sequential explanatory cross-sectional study supplemented with qualitative interviews was employed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      The study was conducted from May 16 to August 30, 2023. Quantitative data were obtained through structured medical chart abstraction, followed by semi-structured interviews to explore barriers to guideline adherence. Data were analyzed using SPSS version 25, and associations between independent variables and asthma control were examined using ordinal logistic regression. Statistical significance was set at\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result:<\/jats:title>\n                    <jats:p>\n                      Findings revealed that patients managed by prescribers not adhering to GINA guidelines had 72% lower odds of achieving symptom control (AOR\u2009=\u20090.28, 95% CI: 0.12\u20130.65,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.003). Positive predictors of symptom control included monthly income of 5501\u20137000 ETB (AOR\u2009=\u20092.12, 95% CI: 1.02\u20134.40), mild persistent asthma compared with severe asthma (AOR\u2009=\u20092.63, 95% CI: 1.00\u20136.89), and use of low- or medium-dose budesonide plus formoterol inhalations daily (AOR\u2009=\u20098.26, 95% CI: 3.26\u201329.1,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.001; AOR\u2009=\u200910.3, 95% CI: 3.27\u201332.6,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001, respectively). Conversely, married (AOR\u2009=\u20090.49, 95% CI: 0.25\u20130.98,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.045) and divorced patients (AOR\u2009=\u20090.39, 95% CI: 0.19\u20130.81,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009=\u20090.012), those prescribed medium-dose beclomethasone with salbutamol (AOR\u2009=\u20090.18, 95% CI: 0.07\u20130.45,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001), and patients with poor medication adherence (AOR\u2009=\u20090.36, 95% CI: 0.22\u20130.61,\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.001) showed significantly lower odds of symptom control. Qualitative findings highlighted barriers such as the extensiveness of the GINA guidelines, limited availability of recommended medications, and insufficient prescriber knowledge and training.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Prescribers\u2019 non-adherence significantly compromised asthma control. Strengthening guideline implementation requires improving medication accessibility, training healthcare providers, and enhancing awareness to optimize asthma management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17534666261436694","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T11:02:07Z","timestamp":1775214127000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Prescriber adherence to asthma treatment guidelines and its impact on symptom control in Ethiopia: a mixed-methods study"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3219-2468","authenticated-orcid":false,"given":"Abraham Nigussie","family":"Assefa","sequence":"first","affiliation":[{"name":"Department of Pharmacy, College of Health Sciences, Debre Tabor University, Main Road, Debre Tabor 272, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muluken Adela","family":"Alemu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5747-7120","authenticated-orcid":false,"given":"Tesfaye Yimer","family":"Tadesse","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanuel Tadesse","family":"Aklog","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology, College of Health Sciences, University of Gondar, Gondar, Amhara Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Getachew Yitayew","family":"Tarekegn","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6813-8792","authenticated-orcid":false,"given":"Tilaye Arega","family":"Moges","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8938-4551","authenticated-orcid":false,"given":"Samuel Berihun","family":"Dagnew","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,3]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202109-2205PP"},{"issue":"2","key":"e_1_3_4_3_2","article-title":"Allergic sensitisation to common antigens among Ethiopian asthmatic patients","volume":"10","author":"Gidey K","year":"2015","unstructured":"Gidey K, Adem A, Guizaw M, et al. 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