{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T08:08:57Z","timestamp":1779091737993,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Program of Shanghai Municipal Health Commission Clinical Research","award":["20234Y0190"],"award-info":[{"award-number":["20234Y0190"]}]},{"name":"Program of Shanghai Municipal Health Commission Clinical Research","award":["20244Y0147"],"award-info":[{"award-number":["20244Y0147"]}]},{"name":"Program of Shanghai Municipal Health Commission Clinical Research","award":["20254Y0012, 2025ZZ1028"],"award-info":[{"award-number":["20254Y0012, 2025ZZ1028"]}]},{"name":"Key Supported Discipline of Health System in Shanghai","award":["2023ZDFC0302"],"award-info":[{"award-number":["2023ZDFC0302"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270114"],"award-info":[{"award-number":["82270114"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82570146"],"award-info":[{"award-number":["82570146"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Municipal Government","award":["KPB2502-1"],"award-info":[{"award-number":["KPB2502-1"]}]},{"name":"Eastern Talent Plan","award":["BJWS2025069"],"award-info":[{"award-number":["BJWS2025069"]}]},{"name":"China Medical and Health Development Foundation","award":["BJ2024JCHX002"],"award-info":[{"award-number":["BJ2024JCHX002"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Cough variant asthma (CVA) is a common cause of chronic cough but remains underdiagnosed due to limited access to bronchial provocation test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To develop a clinical prediction model for CVA based on more accessible indicators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design:<\/jats:title>\n                    <jats:p>A single-center retrospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A retrospective cohort of patients with chronic cough from January 2024 to December 2024 was included. The patients were randomly divided into a training set and an internal validation set at a ratio of 7:3. Univariable and multivariable logistic regression analyses were used to identify independent predictors of CVA. A nomogram prediction model was constructed based on these factors. The predictive performance of the nomogram was evaluated using receiver operating characteristic (ROC) curves, calibration curves, and decision curve analysis (DCA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 323 patients with chronic cough were included, with 226 assigned to the training set (45 with CVA, 181 with non-CVA) and 97 to the internal validation set (23 with CVA, 74 with non-CVA). Multivariable logistic regression analysis identified increased eosinophils in induced sputum, elevated peripheral blood eosinophil count (PBEC), raised FeNO\n                      <jats:sub>50<\/jats:sub>\n                      , and reduced maximal mid-expiratory flow (MMEF) as independent predictors of CVA (all\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&lt;\u20090.05). The nomogram model developed based on these indicators demonstrated strong discriminative ability, with area under the ROC curve (AUC) of 0.93 in the training set and 0.92 in the internal validation set. Calibration curves indicated favorable predictive performance of the model. DCA confirmed net clinical benefit.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      The CVA clinical prediction model based on induced sputum cytology, PBEC, FeNO\n                      <jats:sub>50<\/jats:sub>\n                      and MMEF shows excellent discrimination, accuracy, calibration, and clinical applicability.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17534666261450064","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T07:33:58Z","timestamp":1778830438000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Development of a clinical prediction model for cough variant asthma"],"prefix":"10.1177","volume":"20","author":[{"given":"Haodong","family":"Bai","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baiyi","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tongyangzi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiqing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9980-7933","authenticated-orcid":false,"given":"Wanzhen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1245-2998","authenticated-orcid":false,"given":"Shengyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8713-5332","authenticated-orcid":false,"given":"Xianghuai","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, 389 Xincun Road, Shanghai 200065, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1054-017X","authenticated-orcid":false,"given":"Li","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, Tongji Hospital, School of Medicine, Tongji University, 389 Xincun Road, Shanghai 200065, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"e_1_3_4_2_2","first-page":"13","article-title":"Chinese national guideline on diagnosis and management of cough (2021)","volume":"45","author":"Asthma Group of Chinese Thoracic Society","year":"2022","unstructured":"Asthma Group of Chinese Thoracic Society. Chinese national guideline on diagnosis and management of cough (2021). Chin J Tuberc Respir Dis 2022; 45: 13\u201346.","journal-title":"Chin J Tuberc Respir Dis"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-0441"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2019.07.86"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-025-03661-6"},{"key":"e_1_3_4_6_2","first-page":"208","article-title":"Guidelines for the prevention and management of bronchial asthma (2024 edition)","volume":"48","author":"Chinese Thoracic Society","year":"2025","unstructured":"Chinese Thoracic Society. Guidelines for the prevention and management of bronchial asthma (2024 edition). 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