{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:20:44Z","timestamp":1788186044355,"version":"build-2803163510"},"reference-count":40,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100016250","name":"Lietuvos Sveikatos Moksl\u0173 Universitetas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016250","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2026,6]]},"abstract":"\n Background:<\/jats:title>\n Chronic obstructive pulmonary disease (COPD) is associated with right ventricular (RV) dysfunction and subclinical myocardial injury. The effects of dual bronchodilation on RV function and cardiac injury biomarkers remain limited.<\/jats:p>\n <\/jats:sec>\n \n Objectives:<\/jats:title>\n To evaluate 12-week changes in pulmonary function, RV function, and serum troponin-I in newly-diagnosed COPD patients receiving tiotropium\/olodaterol as routine clinical care and to assess differences in RV function and troponin-I between COPD and non-COPD controls with comparable cardiovascular diseases (CVDs).<\/jats:p>\n <\/jats:sec>\n \n Design:<\/jats:title>\n Prospective real-world observational study.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n Treatment-na\u00efve patients with moderate-to-severe COPD were assessed at baseline and after 12\u2009weeks of treatment. Evaluations included spirometry, plethysmography, two-dimensional and speckle-tracking transthoracic echocardiography, cardiac magnetic resonance imaging (MRI), and troponin-I. Baseline RV measurements and troponin-I were compared between COPD (\n n<\/jats:italic>\n \u2009=\u200947) and controls (\n n<\/jats:italic>\n \u2009=\u200923).\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n COPD patients had lower RV fractional area change and RV free-wall strain (FWS) than controls (\n p<\/jats:italic>\n \u2009<\u20090.001 and\n p<\/jats:italic>\n \u2009=\u20090.018, respectively). Troponin-I was above the limit of detection in 93.6% of COPD and in 56.5% of controls (\n p<\/jats:italic>\n \u2009<\u20090.001). COPD treatment increased forced expiratory volume in 1\u2009second (FEV\n 1<\/jats:sub>\n ) and forced vital capacity while reducing residual volume-to-total lung capacity (TLC) and functional residual capacity (FRC)-to-TLC (\n p<\/jats:italic>\n \u2009<\u20090.05). RV global longitudinal strain (GLS) improved from 21.7\u2009\u00b1\u20092.6% to 23.0\u2009\u00b1\u20092.8%, and RV-FWS from 24.2\u2009\u00b1\u20093.3% to 26.1\u2009\u00b1\u20093.6% (both\n p<\/jats:italic>\n \u2009<\u20090.05) in echocardiography (\n n<\/jats:italic>\n \u2009=\u200929). \u0394RV-GLS correlated positively with \u0394FEV\n 1<\/jats:sub>\n and inversely with \u0394FRC\/TLC (\n p<\/jats:italic>\n \u2009<\u20090.05). In the moderate COPD subgroup, RV-GLS in MRI changed from 22.6\u2009\u00b1\u20096.1% to 25.5\u2009\u00b1\u20097.5% (\n p<\/jats:italic>\n \u2009=\u20090.037), and troponin-I decreased from 1.23\u2009pg\/mL (IQR 1.03\u20131.56) to 1.09\u2009pg\/mL (IQR 0.95\u20131.20;\n p<\/jats:italic>\n \u2009=\u20090.049).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n COPD affects RV function and troponin-I regardless of concomitant CVDs. Initiation of dual bronchodilation is associated with beneficial effects on RV strain and troponin-I in patients with COPD. Because of the small sample size, these findings should be interpreted cautiously and confirmed in larger studies.<\/jats:p>\n <\/jats:sec>\n \n Trial registration:<\/jats:title>\n \n ClinicalTrials.gov; ID NCT06072690;\n https:\/\/clinicaltrials.gov\/study\/NCT06072690<\/jats:ext-link>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1177\/17534666261452491","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T09:27:10Z","timestamp":1782293230000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of dual bronchodilation on right ventricular function and troponin-I in newly diagnosed, moderate-to-severe chronic obstructive pulmonary disease: a prospective real-world observational study"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-1275-1169","authenticated-orcid":false,"given":"Ieva","family":"Dimiene","sequence":"first","affiliation":[{"name":"Department of Pulmonology, Medical Academy, Lithuanian University of Health Sciences, A. 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