{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T07:26:57Z","timestamp":1786951617659,"version":"build-2736575974"},"reference-count":33,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"AstraZeneca China"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Asthma is a common respiratory disease with a high disease burden in China. The patient population with severe asthma remains largely unexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To describe the disease burden, treatment pattern and eosinophilic phenotype of Chinese patients with moderate-to-severe asthma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>This is a retrospective baseline analysis of the real-world, observational, multicenter PRESENT study (NCT06422663).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients receiving Global Initiative for Asthma Step 3\u20135 treatment were categorized into protocol-specified severe asthma (uncontrolled asthma with medium-dose inhaled corticosteroids [ICS], or asthma with high-dose ICS) and moderate asthma subgroups. This baseline analysis reported patient characteristics, disease burden, treatment patterns, eosinophilic phenotype and testing rates of biomarkers at enrolment. Disease burden was assessed by historical asthma exacerbation rate within the past year, Asthma Control Test (ACT) score and lung function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 498 patients included, 203 (40.8%) were identified as having protocol-specified severe asthma. Notable disease burden was observed, as reflected by the high proportion of patients experiencing asthma exacerbation (severe asthma: 35.0%; moderate asthma: 14.6%), low ACT score (mean [SD]: severe asthma: 17.4 [3.8]; moderate asthma: 20.6 [3.7]) and declined pre-bronchodilator forced expiratory volume in one second (pre-BD FEV\n                      <jats:sub>1<\/jats:sub>\n                      ; median [interquartile range]: severe asthma: 2.0 [1.5, 2.5]; moderate asthma: 2.2 [1.7, 2.8]). Overall, testing rates of blood eosinophil (EOS) were 25.3% (in the past seven days), 49.0% (in the past three months) and 68.9% (in the past one year). Among patients who tested EOS once and twice in the past one year, 62.5% (180\/288) and 76.4% (42\/55) had blood EOS counts \u2265150 cells\/\u03bcL, respectively. Testing rates of different biomarkers varied but were generally low.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Notable disease burden and sub-optimal management were observed in Chinese patients with moderate-to-severe asthma. Biomarker-based phenotyping of severe asthma was unsatisfactory. Treatment escalation and routine monitoring of blood EOS level might be considered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                      , NCT06422663, registered on March 19, 2024,\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/study\/NCT06422663\">https:\/\/clinicaltrials.gov\/study\/NCT06422663<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17534666261475564","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T23:40:59Z","timestamp":1786750859000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Disease burden and eosinophilic phenotype in Chinese patients with moderate-to-severe asthma: Baseline analysis of a prospective, multicenter study (PRESENT)"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1054-017X","authenticated-orcid":false,"given":"Li","family":"Yu","sequence":"first","affiliation":[{"name":"Tongji University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"He","sequence":"additional","affiliation":[{"name":"Anning First People\u2019s Hospital Affiliated to Kunming University of Science and Technology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuewen","family":"Jiang","sequence":"additional","affiliation":[{"name":"Qiyang People\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Wang","sequence":"additional","affiliation":[{"name":"West China Hospital of Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Feng","sequence":"additional","affiliation":[{"name":"Nanbu People\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixiu","family":"Chen","sequence":"additional","affiliation":[{"name":"Zhangjiagang First People\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kewu","family":"Huang","sequence":"additional","affiliation":[{"name":"Capital Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Wu","sequence":"additional","affiliation":[{"name":"The First People\u2019s Hospital of Xiaoshan District"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhen","sequence":"additional","affiliation":[{"name":"Dingzhou People\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Cao","sequence":"additional","affiliation":[{"name":"Tianjin Medical University General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuoyan","family":"Li","sequence":"additional","affiliation":[{"name":"Liaoning Province Health Industry Group Iron Coal General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6612-7413","authenticated-orcid":false,"given":"Zhongmin","family":"Qiu","sequence":"additional","affiliation":[{"name":"Tongji University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,14]]},"reference":[{"key":"e_1_3_8_2_2","unstructured":"Global Asthma Network. 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