{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T17:16:01Z","timestamp":1788023761365,"version":"build-2784847793"},"reference-count":24,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with infection- or injury-related benign airway stenosis often require repeated bronchoscopic interventions, but evidence is limited on how early treatment patterns can guide follow-up and risk reassessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To derive phase-adapted surveillance windows after bronchoscopic intervention and determine whether the 24-week treatment trajectory identifies patients at increased risk of subsequent recurrence or progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Two-center retrospective longitudinal cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients treated between January 2019 and December 2024 were included if they had infection- or injury-related benign airway stenosis and did not receive stent or T-tube placement during follow-up. Adjacent bronchoscopic records separated by \u22641 week were merged into one treatment episode. Valid intervals were defined as adjacent records separated by &gt;1 week with assessable recurrence\/progression status. Risk strata were constructed using treatment episodes within 24 weeks and window-end airway control: low risk, 1\u20133 episodes with adequate control; intermediate risk, 4\u20135 episodes or 1\u20133 episodes with inadequate control; and high risk, \u22656 episodes. A 24-week landmark analysis evaluated subsequent composite events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 213 patients contributed 879 valid intervals. Data-informed surveillance windows were approximately 1 week in the early phase, 2\u20133 weeks in the mid and consolidation phases, and 4\u20135 weeks in the maintenance phase. Among 93 patients included in landmark analysis, post-landmark composite event proportions were 31.3%, 60.9%, and 80.6% in the low-, intermediate-, and high-risk groups, respectively (log-rank P&lt;0.001). In multivariable Cox regression, the high-risk group had a significantly increased risk of composite events (HR=5.849, 95% CI 2.031\u201316.845, P=0.001), whereas the intermediate-risk group showed a non-significant trend (HR=2.514, 95% CI 0.920\u20136.871, P=0.072).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Early treatment burden provides clinically meaningful risk stratification after bronchoscopic intervention for benign airway stenosis. Six or more treatment episodes within 24 weeks may identify a treatment-dependent high-risk phenotype requiring intensified surveillance and comprehensive reassessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17534666261483782","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:38:22Z","timestamp":1787776702000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Early treatment burden predicts recurrence or progression after bronchoscopic intervention for infection- or injury-related benign airway stenosis: A two-center longitudinal cohort study"],"prefix":"10.1177","volume":"20","author":[{"given":"Jiaping","family":"Liu","sequence":"first","affiliation":[{"name":"Beijing University of Chinese Medicine"},{"name":"Beijing University of Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhina","family":"Wang","sequence":"additional","affiliation":[{"name":"Emergency General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Lin","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng","family":"Zou","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujuan","family":"Pan","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuiping","family":"Chen","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine"},{"name":"Beijing University of Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Gao","sequence":"additional","affiliation":[{"name":"Emergency General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Emergency General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6401-977X","authenticated-orcid":false,"given":"Hongwu","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"issue":"6","key":"e_1_3_8_2_2","first-page":"647","article-title":"Expert consensus on bronchoscopic interventional diagnosis and treatment of malignant central airway stenosis","volume":"10","author":"Jin F","year":"2017","unstructured":"Jin F, Li S, Wang H. Expert consensus on bronchoscopic interventional diagnosis and treatment of malignant central airway stenosis. Chin J Lung Dis (Electron Ed) 2017; 10(6): 647\u2013654.","journal-title":"Chin J Lung Dis (Electron Ed)"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-22-1734"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pulmoe.2019.12.004"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.21037\/jovs-24-29"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2008.10.041"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.5761\/atcs.oa.18-00073"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.21037\/jtd-24-727"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-025-09230-1"},{"issue":"6","key":"e_1_3_8_10_2","first-page":"408","article-title":"Expert consensus on bronchoscopic interventional diagnosis and treatment of benign central airway stenosis","volume":"40","author":"Chinese Thoracic Society, Chinese Medical Association","year":"2017","unstructured":"Chinese Thoracic Society, Chinese Medical Association. Expert consensus on bronchoscopic interventional diagnosis and treatment of benign central airway stenosis. Chin J Tuberc Respir Dis 2017; 40(6): 408\u2013418.","journal-title":"Chin J Tuberc Respir Dis"},{"issue":"9","key":"e_1_3_8_11_2","first-page":"739","article-title":"Diagnosis and endoluminal treatment of central airway stenosis","volume":"14","author":"Wang HW","year":"2011","unstructured":"Wang HW, Zhang HB. Diagnosis and endoluminal treatment of central airway stenosis. Chin J Lung Cancer 2011; 14(9): 739\u2013743. https:\/\/doi.org\/10.3779\/j.issn.1009-3419.2011.09.08","journal-title":"Chin J Lung Cancer"},{"key":"e_1_3_8_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-024-03384-0"},{"key":"e_1_3_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2024.06.3804"},{"key":"e_1_3_8_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-023-10299-7"},{"key":"e_1_3_8_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-019-06551-8"},{"key":"e_1_3_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61602-X"},{"key":"e_1_3_8_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2466-8-18"},{"key":"e_1_3_8_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.27079"},{"key":"e_1_3_8_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-024-08602-3"},{"key":"e_1_3_8_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/1753466619831966"},{"issue":"2","key":"e_1_3_8_21_2","first-page":"S153","article-title":"Reresection for recurrent stenosis after primary tracheal repair","volume":"8","author":"Madariaga ML","year":"2016","unstructured":"Madariaga ML, Gaissert HA. Reresection for recurrent stenosis after primary tracheal repair. Journal of thoracic disease 2016; 8(Suppl 2): S153\u2013S159. https:\/\/doi.org\/10.3978\/j.issn.2072-1439.2016.01.66","journal-title":"Journal of thoracic disease"},{"key":"e_1_3_8_22_2","first-page":"2379814","article-title":"Efficacy and Safety Profile of Montgomery T-Tube Implantation in Patients with Tracheal Stenosis","volume":"2020","author":"Wu FJ","year":"2020","unstructured":"Wu FJ, Yao YW, Chen EG, et al. Efficacy and Safety Profile of Montgomery T-Tube Implantation in Patients with Tracheal Stenosis. Can Respir J 2020; 2020: 2379814. https:\/\/doi.org\/10.1155\/2020\/2379814","journal-title":"Can Respir J"},{"key":"e_1_3_8_23_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2026.1741311"},{"key":"e_1_3_8_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2018-212732"},{"key":"e_1_3_8_25_2","doi-asserted-by":"publisher","DOI":"10.1177\/17534666231181269"}],"container-title":["Therapeutic Advances in Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17534666261483782","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17534666261483782","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17534666261483782","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T16:19:37Z","timestamp":1788020377000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17534666261483782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":24,"alternative-id":["10.1177\/17534666261483782"],"URL":"https:\/\/doi.org\/10.1177\/17534666261483782","relation":{"has-review":[{"id-type":"doi","id":"10.1177\/17534666261483782\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666261483782\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666261483782\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666261483782\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666261483782\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666261483782\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666261483782\/v1\/review4","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666261483782\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666261483782\/v2\/response1","asserted-by":"object"}]},"ISSN":["1753-4666","1753-4666"],"issn-type":[{"value":"1753-4666","type":"print"},{"value":"1753-4666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"article-number":"17534666261483782"}}