{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T04:12:54Z","timestamp":1788581574789,"version":"build-2803163510"},"reference-count":40,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100005006","name":"Asan Institute for Life Sciences, Asan Medical Center","doi-asserted-by":"publisher","award":["2024IF0013"],"award-info":[{"award-number":["2024IF0013"]}],"id":[{"id":"10.13039\/501100005006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"crossref","award":["RS-2025-00556764"],"award-info":[{"award-number":["RS-2025-00556764"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although hospitalization in idiopathic pulmonary fibrosis (IPF) is associated with poor outcomes, it occurs during the disease course and may lead to overestimation of its prognostic impact when analyzed as a fixed exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to evaluate the association between hospitalization and transplantation-free survival in patients with IPF by modeling hospitalization as a time-dependent exposure and applying a standardized definition of respiratory-related hospitalization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>This was a retrospective cohort study conducted at Asan Medical Center, a tertiary referral center in Seoul, South Korea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 223 patients with IPF were included. Hospitalization was treated as a time-dependent exposure in Cox regression models. Changes in pulmonary function and exercise capacity before and after hospitalization were assessed using linear mixed-effects models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy patients (31%) experienced hospitalization during follow-up, whereas 153 (69%) did not. Hospitalized patients had significantly worse lung function and exercise capacity at baseline compared with non-hospitalized patients. When modeled as a time-dependent exposure, hospitalization was strongly associated with increased risk of transplantation or death (adjusted hazard ratio: 8.87, 95% confidence interval [CI]: 5.57\u201314.11;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001). After excluding patients who died within 10 days of hospitalization, long hospital stay (\u226510 days) was associated with poorer transplantation-free survival than short stay (&lt;10 days) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.022). Pulmonary function and exercise capacity declined significantly during hospitalization. Forced vital capacity decreased both before (\u22127.6%, 95% CI: \u221211.2 to \u22124.1;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt;0.001) and after hospitalization (\u22124.8%, 95% CI: \u22129.4 to \u22120.2;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      =0.04). Minimum oxygen saturation during the six-minute walk test decreased significantly both before (\u22122.5%, 95% CI: \u22123.8 to \u22121.3; P&lt;0.001) and after hospitalization (\u22122.3%, 95% CI: \u22124.4 to \u22120.3; P=0.029).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Hospitalization in IPF was associated with poorer transplantation-free survival and subsequent physiological decline. It may serve as an important time-dependent marker of clinical deterioration and disease progression.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17534666261484857","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T13:46:46Z","timestamp":1788356806000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical impact of hospitalization in patients with idiopathic pulmonary fibrosis: A retrospective cohort study"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0073-2079","authenticated-orcid":false,"given":"Min Jee","family":"Kim","sequence":"first","affiliation":[{"name":"Asan Medical Center"},{"name":"University of Ulsan College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5766-8697","authenticated-orcid":false,"given":"Hyun Seok","family":"Kwak","sequence":"additional","affiliation":[{"name":"Asan Medical Center"},{"name":"University of Ulsan College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sehee","family":"Kim","sequence":"additional","affiliation":[{"name":"Asan Medical Center"},{"name":"University of Ulsan College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3154-4858","authenticated-orcid":false,"given":"Ho Cheol","family":"Kim","sequence":"additional","affiliation":[{"name":"Asan Medical Center"},{"name":"University of Ulsan College of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201006-0894CI"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-023-02503-5"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00957-2022"},{"key":"e_1_3_8_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402582"},{"key":"e_1_3_8_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2414108"},{"key":"e_1_3_8_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402584"},{"key":"e_1_3_8_8_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201105-0840OC"},{"key":"e_1_3_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2019.11.042"},{"key":"e_1_3_8_10_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-023-02588-y"},{"key":"e_1_3_8_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8122069"},{"key":"e_1_3_8_12_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202309-1708OC"},{"key":"e_1_3_8_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-020-01335-x"},{"key":"e_1_3_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30356-8"},{"key":"e_1_3_8_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2008470"},{"key":"e_1_3_8_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.22960"},{"key":"e_1_3_8_17_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202202-0399ST"},{"key":"e_1_3_8_18_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034905"},{"key":"e_1_3_8_19_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"e_1_3_8_20_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00035005"},{"key":"e_1_3_8_21_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00150314"},{"key":"e_1_3_8_22_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201604-0801CI"},{"key":"e_1_3_8_23_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0166462"},{"key":"e_1_3_8_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-021-01851-4"},{"key":"e_1_3_8_25_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-147-8-200710160-00010"},{"key":"e_1_3_8_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4780030106"},{"key":"e_1_3_8_27_2","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00402-2025"},{"key":"e_1_3_8_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-019-00270-z"},{"key":"e_1_3_8_29_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000023143"},{"issue":"1","key":"e_1_3_8_30_2","first-page":"156","article-title":"The Impact of Chronic Comorbidities on Outcomes in Acute Exacerbations of Idiopathic Pulmonary Fibrosis","volume":"14","author":"Baig SH","year":"2024","unstructured":"Baig SH, Yoo EJ. The Impact of Chronic Comorbidities on Outcomes in Acute Exacerbations of Idiopathic Pulmonary Fibrosis. Life (Basel) 2024; 14(1): 156. https:\/\/doi.org\/10.3390\/life14010156","journal-title":"Life (Basel)"},{"key":"e_1_3_8_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12920"},{"key":"e_1_3_8_32_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10173864"},{"key":"e_1_3_8_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-022-02242-y"},{"key":"e_1_3_8_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(14)70124-9"},{"key":"e_1_3_8_35_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4759040"},{"key":"e_1_3_8_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2022.08.2233"},{"key":"e_1_3_8_37_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-017-0621-y"},{"key":"e_1_3_8_38_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-2424"},{"key":"e_1_3_8_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0242860"},{"key":"e_1_3_8_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2018.09.011"},{"key":"e_1_3_8_41_2","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00636-2023"}],"container-title":["Therapeutic Advances in Respiratory Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17534666261484857","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17534666261484857","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17534666261484857","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T03:47:45Z","timestamp":1788580065000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17534666261484857"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":40,"alternative-id":["10.1177\/17534666261484857"],"URL":"https:\/\/doi.org\/10.1177\/17534666261484857","relation":{"has-review":[{"id-type":"doi","id":"10.1177\/17534666261484857\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666261484857\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666261484857\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666261484857\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666261484857\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666261484857\/v1\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666261484857\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1177\/17534666261484857\/v1\/review1","asserted-by":"object"}]},"ISSN":["1753-4666","1753-4666"],"issn-type":[{"value":"1753-4666","type":"print"},{"value":"1753-4666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]},"article-number":"17534666261484857"}}