{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:58:43Z","timestamp":1790845123558,"version":"4.1.0"},"reference-count":58,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Idiopathic pulmonary fibrosis (IPF) represents a chronic and irreversible progressive disease, while acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) represents a catastrophic event in the course of the disease with high mortality. So far, there is no known accurate biomarker with a diagnostic or prognostic role in IPF. Matrix metalloproteases (MMPs), belonging to the family of zinc-containing metallopeptidases, play an active role in extracellular matrix remodeling and in regulating fibrogenesis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The study\u2019s aim was to assess the potential diagnostic and prognostic role of plasma MMP-1 and MMP-9 in IPF and their association to disease progression, acute exacerbation development, and death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Consecutive stable and exacerbated patients referred to our department from October 2013 until December 2017 were enrolled in the study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Demographic, clinical, and laboratory data were collected. MMP-1 and MMP-9 plasma concentrations were measured. All patients were followed-up until death or until 1\n                      <jats:sup>st<\/jats:sup>\n                      July 2020. We analyzed data using tobit regression analysis, Kaplan-Meier analysis, Cox regression analysis, and fractional polynomials.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One hundred twenty-eight patients were included in the study [74 stable IPF patients, mean age (SD) 71.5 years (8.05) and 54 exacerbated, mean age (SD) 71.8 years (10.15)] as well as 26 healthy controls, mean age (SD) 61.4 years (10.4). At baseline, both stable IPF and exacerbated patients presented higher concentrations of MMP-9 in plasma compared to healthy controls independently of age, sex, and smoking (p=0.006 and p=0.002, respectively). In stable IPF, each 1 \u00b5g\/L increase in plasma MMP-1 concentration at baseline was associated with an increase in the hazard rate of death by 20% (95%CI: 2% to 42%; adjusted for age, sex, smoking and FVC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In our patients with stable IPF, MMP-1 concentration is prognostic for death, whereas MMP-9 has diagnostic value for IPF. These results may lead to better patient stratification and personalized therapeutic approaches.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17534666261493434","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:17:42Z","timestamp":1790659062000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["The diagnostic and prognostic role of MMP-1 and MMP-9 plasma concentrations in idiopathic pulmonary fibrosis"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9978-4823","authenticated-orcid":false,"given":"Ioannis","family":"Tomos","sequence":"first","affiliation":[{"name":"SOTIRIA Chest Diseases Hospital of Athens"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aris","family":"Spathis","sequence":"additional","affiliation":[{"name":"National and Kapodistrian University of Athens"},{"name":"\u201cATTIKON\u201d University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stylianos","family":"Argentos","sequence":"additional","affiliation":[{"name":"ATTIKON University Hospital"},{"name":"National and Kapodistrian University of Athens"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Karakatsani","sequence":"additional","affiliation":[{"name":"National and Kapodistrian University of Athens"},{"name":"\u201cATTIKON\u201d University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Effrosyni D.","family":"Manali","sequence":"additional","affiliation":[{"name":"National and Kapodistrian University of Athens"},{"name":"\u201cATTIKON\u201d University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spyros","family":"Papiris","sequence":"additional","affiliation":[{"name":"National and Kapodistrian University of Athens"},{"name":"\u201cATTIKON\u201d University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_3_9_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202202-0399ST"},{"key":"e_1_3_9_3_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201807-1255ST"},{"key":"e_1_3_9_4_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2009-040GL"},{"key":"e_1_3_9_5_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00158-2025"},{"key":"e_1_3_9_6_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201006-0894CI"},{"key":"e_1_3_9_7_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201604-0801CI"},{"key":"e_1_3_9_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.836553"},{"key":"e_1_3_9_9_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00419-2015"},{"key":"e_1_3_9_10_2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00159709"},{"key":"e_1_3_9_11_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201403-0566OC"},{"key":"e_1_3_9_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/cc9241"},{"key":"e_1_3_9_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62351-6"},{"key":"e_1_3_9_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.74"},{"key":"e_1_3_9_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2017.1300533"},{"key":"e_1_3_9_16_2","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200601-003TK"},{"key":"e_1_3_9_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-016-0245-x"},{"key":"e_1_3_9_18_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI183836"},{"issue":"4","key":"e_1_3_9_19_2","first-page":"1241","article-title":"Immunohistochemical study of metalloproteinases and their tissue inhibitors in the lungs of patients with diffuse alveolar damage and idiopathic pulmonary fibrosis","volume":"149","author":"Hayashi T","year":"1996","unstructured":"Hayashi T, Stetler-Stevenson WG, Fleming MV, et al. 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