{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T08:36:54Z","timestamp":1792917414948,"version":"4.5.0"},"reference-count":36,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"publisher","award":["TCVGH-1103203C"],"award-info":[{"award-number":["TCVGH-1103203C"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"publisher","award":["TCVGH-1133203C"],"award-info":[{"award-number":["TCVGH-1133203C"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"publisher","award":["TCVGH-1143302C"],"award-info":[{"award-number":["TCVGH-1143302C"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010101","name":"Taichung Veterans General Hospital","doi-asserted-by":"publisher","award":["TCVGH-1153304A"],"award-info":[{"award-number":["TCVGH-1153304A"]}],"id":[{"id":"10.13039\/501100010101","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Disease stability (DS) has been proposed as a multidimensional measure of disease activity in chronic obstructive pulmonary disease, but its longitudinal behavior and the clinical relevance of early DS remain poorly characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To characterize longitudinal DS and determine whether DS at 6 months is associated with DS at 12 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Retrospective multicenter cohort study conducted at four hospitals in Taiwan between January 2016 and December 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with complete exacerbation records, spirometry data, and Chronic Airways Assessment Test (CAAT) data at baseline and at the 6- and 12-month assessments were included. DS was defined as the absence of moderate or severe exacerbations, &lt;2-point worsening from baseline in CAAT score, and &lt;100-mL decline in post-bronchodilator forced expiratory volume in one second. Multivariable logistic regression analyses were used to evaluate factors associated with DS and the association between 6- and 12-month DS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 905 patients identified, 250 had complete longitudinal data and comprised the primary analytic cohort. DS was achieved by 114 patients (45.6%) at 6 months and 94 (37.6%) at 12 months. Among patients with and without 6-month DS, 68.4% and 11.8%, respectively, achieved 12-month DS. In the baseline multivariable model, prior moderate or severe exacerbations (adjusted odds ratio [aOR]: 0.25, 95% confidence interval [CI]: 0.12\u20130.53) and reliever use of \u22653 canisters\/year (aOR: 0.50, 95% CI: 0.27\u20130.95) were associated with lower odds of 12-month DS. After additional adjustment for 6-month DS, achievement of 6-month DS was strongly associated with 12-month DS (aOR: 11.72, 95% CI: 5.67\u201324.22). This association remained consistent in the expanded ascertainable-outcome cohort (N = 544; aOR: 14.33, 95% CI: 7.30\u201328.14) and the multiple-imputation analysis of the full cohort (N = 905; aOR: 13.57, 95% CI: 8.39\u201321.93).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Six-month DS was strongly associated with subsequent DS and may represent a clinically relevant intermediate milestone for characterizing disease trajectory and identifying patients who may benefit from closer monitoring and management reassessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17534666261500324","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:03:59Z","timestamp":1792685039000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association between six-month and 12-month disease stability in chronic obstructive pulmonary disease: A multicenter real-world cohort study"],"prefix":"10.1177","volume":"20","author":[{"given":"Wei-Fan","family":"Ou","sequence":"first","affiliation":[{"name":"Taichung Veterans General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2479-2404","authenticated-orcid":false,"given":"Yi-Luen","family":"Shen","sequence":"additional","affiliation":[{"name":"Asia University Hospital"},{"name":"National Chung Hsing University"},{"name":"National Chung Hsing University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Wen","family":"Huang","sequence":"additional","affiliation":[{"name":"Asia University Hospital"},{"name":"Asia University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Hui","sequence":"additional","affiliation":[{"name":"Cheng Ching General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-An","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Asia University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-Tung","family":"Wang","sequence":"additional","affiliation":[{"name":"Chung Shan Medical University Hospital"},{"name":"Chung Shan Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9733-5899","authenticated-orcid":false,"given":"Wei-Chang","family":"Huang","sequence":"additional","affiliation":[{"name":"Taichung Veterans General Hospital"},{"name":"Chung Shan Medical University"},{"name":"National Chung Hsing University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"e_1_3_8_2_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202204-0671PP"},{"key":"e_1_3_8_3_2","doi-asserted-by":"publisher","DOI":"10.1183\/20734735.026410"},{"key":"e_1_3_8_4_2","doi-asserted-by":"publisher","DOI":"10.1385\/CRIAI:27:1:035"},{"key":"e_1_3_8_5_2","first-page":"101035","article-title":"Impact of pharmacological and non-pharmacological interventions on mortality in chronic obstructive pulmonary disease (COPD) patients","volume":"84","author":"Zysman M","year":"2023","unstructured":"Zysman M, Mahay G, Guibert N, et al. 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