{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T13:48:37Z","timestamp":1793022517294,"version":"4.5.0"},"reference-count":38,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"Young-middle-aged Academic and Technical Leaders Reserve Talent Program of Yunnan Province","award":["202305AC160017"],"award-info":[{"award-number":["202305AC160017"]}]},{"name":"535 Talent Project of First Affiliated Hospital of Kunming Medical University","award":["2023535D12"],"award-info":[{"award-number":["2023535D12"]}],"id":[{"id":"https:\/\/ror.org\/02g01ht84","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160007"],"award-info":[{"award-number":["82160007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health Commission of Yunnan Province - Clinical Medical Center for Emergency Traumatic Disease","award":["2024YNLCYXZX0001"],"award-info":[{"award-number":["2024YNLCYXZX0001"]}]},{"name":"\u201cXingdian Talents\u201d Support Project of Yunnan Province"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Ther Adv Respir Dis"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite the substantial disease burden of chronic obstructive pulmonary disease (COPD), convenient and specific biomarkers for COPD remain lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To explore plasma bone morphogenetic protein 2 (BMP2) levels in patients with COPD and the diagnostic value of BMP2 for COPD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A single-center and cross-sectional observational study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Ninety-one patients with COPD and 51 healthy subjects were prospectively recruited as the COPD group and control group, respectively. Plasma BMP2 levels of all subjects were detected. Correlations between BMP2 and other clinical indicators were analyzed. Logistic regression analysis was used to identify the risk factors of COPD. The ROC curve was used to evaluate the diagnostic value of BMP2 for COPD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Plasma BMP2 levels in COPD group were higher than that in control group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). The COPD group was divided into acute exacerbation of COPD (AECOPD) group (n=59) and stable COPD (SCOPD) group (n=32). Plasma BMP2 levels in the SCOPD group were higher than that in the AECOPD group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). In addition, plasma BMP2 levels in the control group and COPD group were negatively correlated with PEF, FEF\n                      <jats:sub>25<\/jats:sub>\n                      , FEF\n                      <jats:sub>50<\/jats:sub>\n                      , FEF\n                      <jats:sub>75<\/jats:sub>\n                      , and DLCO (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). Plasma BMP2 in the COPD group were positively correlated with FEV\n                      <jats:sub>1<\/jats:sub>\n                      \/FVC, FEV\n                      <jats:sub>1<\/jats:sub>\n                      %pred, FEF\n                      <jats:sub>25<\/jats:sub>\n                      , FEF\n                      <jats:sub>50<\/jats:sub>\n                      , and FEF\n                      <jats:sub>75<\/jats:sub>\n                      (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). Importantly, logistic regression analysis showed that BMP2 was an independent risk factor for COPD (adjusted OR = 1.115, 95% CI: 1.065\u20131.166,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Moreover, the AUC of BMP2 in distinguishing COPD group from control group was 0.763 (95% CI: 0.686-0.839,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001), and that in distinguishing AECOPD group from SCOPD group was 0.722 (95% CI: 0.610-0.834,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Plasma BMP2 level is elevated in patients with COPD. Moreover, BMP2 is an independent risk factor for COPD and has auxiliary diagnostic value for COPD. Consequently, BMP2 may be a promising biomarker for COPD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17534666261501648","type":"journal-article","created":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T06:30:12Z","timestamp":1792823412000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["BMP2 may be a promising biomarker for COPD"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1442-1727","authenticated-orcid":false,"given":"Yiqiong","family":"Wen","sequence":"first","affiliation":[{"name":"First Affiliated Hospital of Kunming Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0078-7260","authenticated-orcid":false,"given":"Lingyu","family":"Li","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Kunming Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5971-7332","authenticated-orcid":false,"given":"Qiaoli","family":"Fu","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Kunming Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9984-151X","authenticated-orcid":false,"given":"Qingqing","family":"Qian","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Kunming Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0968-5064","authenticated-orcid":false,"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Kunming Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8075-1866","authenticated-orcid":false,"given":"Ting","family":"Li","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Kunming Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8107-3643","authenticated-orcid":false,"given":"Wei","family":"Ma","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Kunming Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1679-9131","authenticated-orcid":false,"given":"Yuanyuan","family":"Zheng","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Kunming Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9287-1820","authenticated-orcid":false,"given":"Shibo","family":"Sun","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Kunming Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,10,23]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2026.1722371"},{"key":"e_1_3_7_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(24)00339-4"},{"key":"e_1_3_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2025.03.029"},{"key":"e_1_3_7_5_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics15101245"},{"key":"e_1_3_7_6_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-025-03356-w"},{"key":"e_1_3_7_7_2","doi-asserted-by":"publisher","DOI":"10.46747\/cfp.6710751"},{"key":"e_1_3_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2026.06.035"},{"key":"e_1_3_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2024.05.011"},{"key":"e_1_3_7_10_2","doi-asserted-by":"publisher","DOI":"10.62347\/MCZH5861"},{"key":"e_1_3_7_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14093132"},{"key":"e_1_3_7_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-025-00497-y"},{"key":"e_1_3_7_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-024-01181-7"},{"key":"e_1_3_7_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.663987"},{"key":"e_1_3_7_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14111340"},{"key":"e_1_3_7_16_2","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S436323"},{"key":"e_1_3_7_17_2","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2014-0029OC"},{"key":"e_1_3_7_18_2","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0112-2021"},{"key":"e_1_3_7_19_2","article-title":"Global strategy for prevention","author":"Global Initiative for Chronic Obstructive Lung Disease (GOLD)","year":"2024","unstructured":"Global Initiative for Chronic Obstructive Lung Disease (GOLD). 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