{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T03:11:22Z","timestamp":1780629082227,"version":"3.54.1"},"reference-count":38,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2013,8,9]],"date-time":"2013-08-09T00:00:00Z","timestamp":1376006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Obstet Med"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p> Aortopathies, or disease affecting the aorta, are associated with a significant mortality risk for the mother and foetus during pregnancy because of an increased rate of aortic dissection. The hereditary aortopathies; Marfan\u2019s syndrome, bicuspid aortic valve, Loeys\u2013Dietz syndrome, Ehlers\u2013Danlos (type IV) syndrome, Turner\u2019s syndrome and nonsyndromic familial thoracic aortic aneurysm and dissection are all associated with an increased risk of aortic dissection particularly during the third trimester and early postpartum period. Maternal outcome in pregnancy depends on the underlying disorder and the aortic dimensions prior to pregnancy. The foetus has up to 50% chance of inheriting the underlying genetic defect. Vasculitis, particularly Takayasu\u2019s arteritis may also be a problem in pregnancy and predispose to aortic dissection. Prepregnancy review, including careful assessment of the aorta and prophylactic aortic surgery for an aortic aneurysm may reduce the risk of aortic dissection in pregnancy for some of the aortopathies but for women with Marfan\u2019s syndrome, Loeys\u2013Dietz syndrome and Ehlers\u2013Danlos (vascular type IV) who have had surgery, the risk of death remains high. A subgroup of women with Marfan\u2019s syndrome or a bicuspid aortic valve and normal aortic dimensions prepregnancy should do well in a pregnancy. Multidisciplinary pregnancy care with agreement on pregnancy follow-up, delivery and postpartum care with a crisis plan for an aortic dissection can improve pregnancy outcome and ensure prompt management of an aortic dissection should it occur. <\/jats:p>","DOI":"10.1177\/1753495x13496237","type":"journal-article","created":{"date-parts":[[2013,8,10]],"date-time":"2013-08-10T04:04:28Z","timestamp":1376107468000},"page":"112-119","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":16,"title":["Marfan\u2019s syndrome and other aortopathies in pregnancy"],"prefix":"10.1177","volume":"6","author":[{"given":"Fiona M","family":"Stewart","sequence":"first","affiliation":[{"name":"Greenlane Cardiovascular Service and National Women\u2019s Health, Auckland City Hospital, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,8,9]]},"reference":[{"key":"bibr1-1753495X13496237","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-20-3-486"},{"key":"bibr2-1753495X13496237","volume-title":"CEMACH saving mothers\u2019 lives: reviewing maternal deaths to make motherhood safer-2003-2005: The Seventh Report on Confidential Enquiries into Maternal Deaths in the United Kingdom","author":"CEMACH","year":"2008"},{"key":"bibr3-1753495X13496237","volume-title":"Maternal deaths in Australia 2003-2005. 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