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Specific maternal conditions that can affect the performance of noninvasive prenatal testing include obesity, active autoimmune disease and low molecular weight heparin treatment. There is also a growing appreciation of the implications of discordant noninvasive prenatal testing results for maternal health, including unexpected diagnoses of maternal chromosomal conditions, or rarely, occult cancer. The interrelatedness of noninvasive prenatal testing and maternal health mean that the longstanding principles underpinning prenatal screening \u2013 voluntary testing, informed decision making, availability of specialist genetic counselling and well-defined clinical pathways \u2013 are more important than ever before. <\/jats:p>","DOI":"10.1177\/1753495x16652007","type":"journal-article","created":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T02:30:02Z","timestamp":1465353002000},"page":"148-152","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":25,"title":["Noninvasive prenatal testing for aneuploidy using cell-free DNA \u2013 New implications for maternal health"],"prefix":"10.1177","volume":"9","author":[{"given":"Lisa","family":"Hui","sequence":"first","affiliation":[{"name":"Department of Perinatal Medicine, The Mercy Hospital for Women, Heidelberg, Australia"},{"name":"Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Australia"},{"name":"Public Health Genetics, Murdoch Childrens Research Institute, Parkville, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,6,22]]},"reference":[{"key":"bibr1-1753495X16652007","doi-asserted-by":"crossref","unstructured":"Gahan PB (ed). 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