{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T04:33:32Z","timestamp":1787978012001,"version":"build-2784847793"},"reference-count":45,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T00:00:00Z","timestamp":1537315200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Obstet Med"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the impact of medical and obstetric complications associated with mixed connective tissue disease (MCTD) in pregnancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We analyzed 68 pregnancies from a systematic literature review and 12 pregnancies affected by MCTD at our centre between 1986 and 2015 for medical and obstetric complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During pregnancy 37.1% had active MCTD and 26.7% had relapsed. Maternal complications included caesarean section (31.1%,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200919), preeclampsia (17.6%,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200913), thromboembolism events, and death (2.5%,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u20092 for each). Fetal complications included prematurity (48.1%,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200925), intrauterine growth restriction (38.3%,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200919), and neonatal lupus (28.6%,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200918, including chondrodysplasia punctata). More than half (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200910) of the neonatal lupus cases were explained by anti-U\n                      <jats:sub>1<\/jats:sub>\n                      RNP only. The perinatal mortality rate was 17.7% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      \u2009=\u200914). Pregnant women with active disease had higher rates of prematurity (OR\u2009=\u20097.60; 95%CI [1.93; 29.95]) and perinatal death (OR\u2009=\u200916.83; 95%CI [1.90; 147.70]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MCTD in pregnancy puts women at risk of medical and obstetric complications, and disease activity probably increases this risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1753495x18793484","type":"journal-article","created":{"date-parts":[[2018,9,20]],"date-time":"2018-09-20T01:19:58Z","timestamp":1537406398000},"page":"31-37","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":13,"title":["Mixed connective tissue disease in pregnancy: A case series and systematic literature review"],"prefix":"10.1177","volume":"12","author":[{"given":"Marie-Lou","family":"Tardif","sequence":"first","affiliation":[{"name":"Internal Medicine Division, Department of Medicine, <!---->Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CHUM)<!---->, Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mich\u00e8le","family":"Mahone","sequence":"additional","affiliation":[{"name":"Internal Medicine Division, Department of Medicine, <!---->Centre Hospitalier de l\u2019Universit\u00e9 de Montr\u00e9al (CHUM)<!---->, Montr\u00e9al, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,9,19]]},"reference":[{"key":"e_1_3_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2005.04.001"},{"key":"e_1_3_7_3_2","first-page":"328","article-title":"Comparison between 3 diagnostic criteria for mixed connective tissue disease. 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