{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:45:36Z","timestamp":1782539136888,"version":"3.54.5"},"reference-count":21,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T00:00:00Z","timestamp":1546905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Obstet Med"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:p> Rituximab targets the CD20 antigen expressed on B-lymphocytes and is used to treat recurrent minimal change disease, but experience of its use in pregnancy is limited. We describe a 28-year-old Caucasian female, with recurrent nephrotic syndrome secondary to minimal change disease. She had failed to respond to non-teratogenic alternative therapies. The patient was successfully maintained in remission with rituximab during two consecutive pregnancies. Rituximab (1 g) was administered at 14<jats:sup>+6<\/jats:sup> weeks 14 weeks and 6 days during Pregnancy 1 and 500 mg administered at 23<jats:sup>+4<\/jats:sup> weeks 23 weeks and 4 days of Pregnancy 2. Rituximab had no apparent effect on infant B-cell development in either pregnancy, as neonatal lymphocyte titres were within normal range. There were no maternal complications in either pregnancy. Neither infant encountered infection-related complications. Although rituximab administration during pregnancy appeared safe, evidence of placental transfer is reported with neonatal B-cell depletion, thus alternatives with known safety profiles in pregnancy should be considered before rituximab administration. <\/jats:p>","DOI":"10.1177\/1753495x18813739","type":"journal-article","created":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T19:37:53Z","timestamp":1547062673000},"page":"145-147","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Rituximab for the maintenance of minimal change nephropathy \u2013 A report of two pregnancies"],"prefix":"10.1177","volume":"13","author":[{"given":"Francesca","family":"Holden","sequence":"first","affiliation":[{"name":"Department of Nephrology and Obstetrics, King\u2019s College Hospital NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Bramham","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Obstetrics, King\u2019s College Hospital NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Obstetrics, King\u2019s College Hospital NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,1,8]]},"reference":[{"key":"bibr1-1753495X18813739","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.12.3900.012k14_3900_3908"},{"key":"bibr2-1753495X18813739","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1111\/nep.12744","volume":"21","author":"Papakrivopoulou E","year":"2016","journal-title":"Nephrology (Carlton)"},{"key":"bibr3-1753495X18813739","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013030251"},{"key":"bibr4-1753495X18813739","doi-asserted-by":"crossref","first-page":"46036","DOI":"10.1038\/srep46036","volume":"7","author":"Takura T","year":"2017","journal-title":"Sci Rep"},{"key":"bibr5-1753495X18813739","doi-asserted-by":"publisher","DOI":"10.1159\/000360908"},{"key":"bibr6-1753495X18813739","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1159\/000464475","volume":"45","author":"Brown L","year":"2017","journal-title":"Am J Nephrol"},{"key":"bibr7-1753495X18813739","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfq316"},{"key":"bibr8-1753495X18813739","unstructured":"United States Food and Drug Administration. 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