{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:53:15Z","timestamp":1790488395190,"version":"4.1.0"},"reference-count":19,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2019,1,12]],"date-time":"2019-01-12T00:00:00Z","timestamp":1547251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Obstet Med"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Tacrolimus has been used in pregnant women following transplantation and for management of lupus nephritis. We report a case of successful control of nephrotic syndrome due to membranous glomerulonephritis during pregnancy using tacrolimus. <\/jats:p><\/jats:sec><jats:sec><jats:title>Case report<\/jats:title><jats:p> A 26-year-old female presented with severe nephrotic syndrome in her first pregnancy. Post-partum renal biopsy confirmed idiopathic membranous glomerulonephritis. She had persistent proteinuria of 6 g\/day with hypoalbuminaemia despite angiotensin receptor blockade. Treatment with tacrolimus monotherapy led to remission of proteinuria, three months prior to conceiving again. She maintained remission with tacrolimus therapy in pregnancy, resulting in a successful birth outcome. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> Membranous glomerulonephritis can be successfully and safely managed with tacrolimus monotherapy during pregnancy. This provides an alternative immunosuppressant with a favourable side effect profile suitable for use in women planning a pregnancy when other immunosuppressive drugs should be avoided. <\/jats:p><\/jats:sec>","DOI":"10.1177\/1753495x18816923","type":"journal-article","created":{"date-parts":[[2019,1,12]],"date-time":"2019-01-12T13:40:06Z","timestamp":1547300406000},"page":"148-150","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Case study of tacrolimus as an effective treatment for idiopathic membranous glomerulonephritis in pregnancy"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0758-1867","authenticated-orcid":false,"given":"GL","family":"Irish","sequence":"first","affiliation":[{"name":"Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, Australia"},{"name":"Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Jesudason","sequence":"additional","affiliation":[{"name":"Central and Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, Australia"},{"name":"Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,1,12]]},"reference":[{"key":"bibr1-1753495X18816923","doi-asserted-by":"publisher","DOI":"10.1159\/000471894"},{"key":"bibr2-1753495X18816923","doi-asserted-by":"publisher","DOI":"10.1159\/000057600"},{"key":"bibr3-1753495X18816923","first-page":"56","volume":"28","author":"Packham DK","year":"1987","journal-title":"Clin Nephrol"},{"key":"bibr4-1753495X18816923","first-page":"106","volume":"29","author":"Jungers P","year":"1988","journal-title":"Clin Nephrol"},{"key":"bibr5-1753495X18816923","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(85)90463-6"},{"key":"bibr6-1753495X18816923","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1986.272"},{"key":"bibr7-1753495X18816923","first-page":"839376","volume":"2015","author":"Ope-Adenuga S","year":"2015","journal-title":"Case Rep Obstet Gynecol"},{"key":"bibr8-1753495X18816923","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00130117"},{"key":"bibr9-1753495X18816923","first-page":"103","volume":"15","author":"Jungers P","year":"1986","journal-title":"Adv Nephrol Necker Hosp"},{"key":"bibr10-1753495X18816923","unstructured":"Kidney Disease: Improving Global Outcomes (KDIGO) Glomerulonephritis Work Group. KDIGO Clinical Practice Guideline for Glomerulonephritis. Kidney inter Suppl 2012; 2: 139\u2013274."},{"key":"bibr11-1753495X18816923","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1994.00420010131015"},{"key":"bibr12-1753495X18816923","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.092163"},{"key":"bibr13-1753495X18816923","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu306"},{"key":"bibr14-1753495X18816923","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002215"},{"key":"bibr15-1753495X18816923","doi-asserted-by":"publisher","DOI":"10.2147\/IJWH.S76819"},{"key":"bibr16-1753495X18816923","doi-asserted-by":"crossref","unstructured":"Mohammadi FA, Borg M, Gulyani A, McDonald SP and Jesudason S. Pregnancy outcomes and impact of pregnancy on graft function in women after kidney transplantation. 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