{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T22:49:29Z","timestamp":1784242169936,"version":"3.55.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2019,2,2]],"date-time":"2019-02-02T00:00:00Z","timestamp":1549065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100016724","name":"Postgraduate Institute of Medical Education and Research, Chandigarh","doi-asserted-by":"crossref","award":["Intramural"],"award-info":[{"award-number":["Intramural"]}],"id":[{"id":"10.13039\/100016724","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Obstet Med"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Plasma brain natriuretic peptide levels were prospectively studied in pregnant women with heart disease. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Fifty pregnant women with heart disease and 25 controls were evaluated at 24 weeks or under, 30\u201332 weeks, 34 weeks or more of gestation, and 6 weeks postpartum. Adverse maternal cardiac events were hospitalization for worsening heart failure, stroke, and death. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Thirty-eight (76%) women had rheumatic heart disease. Plasma brain natriuretic peptide levels were (in cases and controls) 118.3\u2009\u00b1\u200946.5\u2009pg\/ml and 66.3\u2009\u00b1\u200915.9\u2009pg\/ml (at 24 weeks or under), 124.8\u2009\u00b1\u200930.4\u2009pg\/ml and 68.4\u2009\u00b1\u200916.5\u2009pg\/ml (30\u201332 weeks), 135.8\u2009\u00b1\u200934.9\u2009pg\/ml and 68.6\u2009\u00b1\u200915.6\u2009pg\/ml (34 weeks or more), and 110.1\u2009\u00b1\u200921.9\u2009pg\/ml and 65.0\u2009\u00b1\u200916.1\u2009pg\/ml (6 weeks postpartum) (p\u2009=\u2009.0001). Eighteen women had adverse events. Of these, only 1 had a level less than 100\u2009pg\/ml, 12 were between 100 and 200\u2009pg\/ml, and 5 more than 200\u2009pg\/ml. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p> Plasma brain natriuretic peptide levels were higher in women with heart disease at all periods of gestation as well as six weeks postpartum. No woman with a plasma brain natriuretic peptide levels of 98\u2009pg\/ml or less had an adverse event. <\/jats:p><\/jats:sec>","DOI":"10.1177\/1753495x18819351","type":"journal-article","created":{"date-parts":[[2019,2,2]],"date-time":"2019-02-02T12:08:15Z","timestamp":1549109295000},"page":"25-29","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Brain natriuretic peptide in pregnant women with heart disease"],"prefix":"10.1177","volume":"13","author":[{"given":"Karanvir","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6205-0455","authenticated-orcid":false,"given":"Pooja","family":"Sikka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, 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