{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:30:45Z","timestamp":1783431045544,"version":"3.54.6"},"reference-count":12,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T00:00:00Z","timestamp":1567382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Obstet Med"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Current guidelines recommend viral, autoimmune, coagulation and liver ultrasound testing in intrahepatic cholestasis of pregnancy to exclude alternative diagnoses. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> Electronic health records were searched for investigations and diagnoses in women with raised bile acid concentrations (&gt;10\u2009\u00b5mol\/L) between January 2016 and December 2017 at two UK maternity units. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Five hundred and thirty-one women had a raised bile acid concentration (median (IQR): 18 (13\u201332\u2009\u00b5mol\/L)) at a median gestation of 35.1 (IQR 31.8\u201337.0) weeks. Out of 531 women, 250 (47.1%) had full virology, autoimmune and ultrasound tests, and 348 (65.5%) had coagulation performed. Positive hepatitis B and C results were previously known. No new Epstein\u2013Barr virus, cytomegalovirus or hepatitis A diagnoses were made. There were 11 positive autoimmune results, but no new diagnoses. No woman had an unexplained prolonged prothrombin time. No ultrasound liver ( n\u2009=\u200938) or gallbladder ( n\u2009=\u200985) abnormalities were of acute clinical significance. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Intrahepatic cholestasis of pregnancy investigations provided no new diagnoses that influenced clinical management during pregnancy. <\/jats:p><\/jats:sec>","DOI":"10.1177\/1753495x19868873","type":"journal-article","created":{"date-parts":[[2019,9,2]],"date-time":"2019-09-02T15:24:28Z","timestamp":1567437868000},"page":"185-191","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Detection of additional abnormalities or co-morbidities in women with suspected intrahepatic cholestasis of pregnancy"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7081-6839","authenticated-orcid":false,"given":"Frances","family":"Conti-Ramsden","sequence":"first","affiliation":[{"name":"Department of Women and Children\u2019s Health, School of Life Course Sciences, King\u2019s College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"McEwan","sequence":"additional","affiliation":[{"name":"West Middlesex University Hospital, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Women and Children\u2019s Health, School of Life Course Sciences, King\u2019s College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Wade","sequence":"additional","affiliation":[{"name":"Department of Women and Children\u2019s Health, School of Life Course Sciences, King\u2019s College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina","family":"Abraham","sequence":"additional","affiliation":[{"name":"Department of Women and Children\u2019s Health, School of Life Course Sciences, King\u2019s College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Buckeldee","sequence":"additional","affiliation":[{"name":"West Middlesex University Hospital, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Williamson","sequence":"additional","affiliation":[{"name":"Department of Women and Children\u2019s Health, School of Life Course Sciences, King\u2019s College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline L","family":"Knight","sequence":"additional","affiliation":[{"name":"Department of Women and Children\u2019s Health, School of Life Course Sciences, King\u2019s College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Girling","sequence":"additional","affiliation":[{"name":"West Middlesex University Hospital, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy C","family":"Chappell","sequence":"additional","affiliation":[{"name":"Department of Women and Children\u2019s Health, School of Life Course Sciences, King\u2019s College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,9,2]]},"reference":[{"key":"bibr1-1753495X19868873","doi-asserted-by":"crossref","unstructured":"Kenyon AP, Tribe RM, Nelson-Piercy C, et\u00a0al. Pruritus in pregnancy: a study of anatomical distribution and prevalence in relation to the development of obstetric cholestasis. Obstet Med 2010; 3(1): 25\u201329.","DOI":"10.1258\/om.2010.090055"},{"key":"bibr2-1753495X19868873","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2016.02.004"},{"key":"bibr3-1753495X19868873","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2015.12.008"},{"key":"bibr4-1753495X19868873","doi-asserted-by":"publisher","DOI":"10.1586\/17474124.2015.1083857"},{"key":"bibr5-1753495X19868873","author":"Abedin P","journal-title":"Ethn Health"},{"key":"bibr6-1753495X19868873","unstructured":"Kenyon AP, Girling J. Obstetric cholestasis. RCOG Green-top Guideline No. 43, 2011, pp.1\u201314."},{"key":"bibr7-1753495X19868873","doi-asserted-by":"publisher","DOI":"10.1136\/gut.12.2.145"},{"key":"bibr8-1753495X19868873","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2002.01368.x"},{"key":"bibr9-1753495X19868873","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510260216"},{"key":"bibr10-1753495X19868873","first-page":"189","volume":"94","author":"Heinonen S","year":"1999","journal-title":"Obstet Gynecol"},{"key":"bibr11-1753495X19868873","first-page":"1","author":"Dixon PH","year":"2017","journal-title":"Sci Rep"},{"key":"bibr12-1753495X19868873","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2012.09.014"}],"container-title":["Obstetric Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753495X19868873","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1753495X19868873","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753495X19868873","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T14:13:05Z","timestamp":1740751985000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1753495X19868873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,2]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1177\/1753495X19868873"],"URL":"https:\/\/doi.org\/10.1177\/1753495x19868873","relation":{},"ISSN":["1753-495X","1753-4968"],"issn-type":[{"value":"1753-495X","type":"print"},{"value":"1753-4968","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,2]]}}}