{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:04:31Z","timestamp":1790805871276,"version":"4.1.0"},"reference-count":17,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2021,6,20]],"date-time":"2021-06-20T00:00:00Z","timestamp":1624147200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Obstet Med"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To report pregnancy outcomes and complications in women receiving eculizumab for the management of paroxysmal nocturnal haemoglobinuria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A service evaluation of routinely collected medical records across 49 pregnancies in 21 women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eculizumab was used in 37 pregnancies, 31 of which (83.8%) ended in live birth. Eight infants (25.8%) were born prematurely. Over half (54%) of women required increases in their dose of eculizumab to control their haemolysis. There were no reported cases of maternal thrombosis. Major ante\/postpartum bleeding necessitating urgent intervention was reported in 10.8% of pregnancies. There were two cases of intrauterine death and three miscarriages. There were no maternal or neonatal deaths. Three newborns required prolonged hospital stays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Eculizumab appears to benefit pregnant women with paroxysmal nocturnal haemoglobinuria and pregnancy outcomes following its use are largely good.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1753495x211019899","type":"journal-article","created":{"date-parts":[[2021,6,20]],"date-time":"2021-06-20T23:59:06Z","timestamp":1624233546000},"page":"45-49","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Pregnancy outcomes in women receiving eculizumab for the management of paroxysmal nocturnal haemoglobinuria"],"prefix":"10.1177","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4240-659X","authenticated-orcid":false,"given":"James E","family":"Manning","sequence":"first","affiliation":[{"name":"School of Medicine, University of Leeds, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel M","family":"Anderson","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Leeds, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Hill","sequence":"additional","affiliation":[{"name":"Department of Haematology, Leeds Teaching Hospitals NHS Trust, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7863-4033","authenticated-orcid":false,"given":"Doaa","family":"Zeidan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynaecology, Leeds Teaching Hospitals NHS Trust, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"Ciantar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics & Gynaecology, Leeds Teaching Hospitals NHS Trust, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,6,20]]},"reference":[{"key":"bibr1-1753495X211019899","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.28"},{"key":"bibr2-1753495X211019899","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(94)90121-X"},{"key":"bibr3-1753495X211019899","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2010.037531"},{"key":"bibr4-1753495X211019899","doi-asserted-by":"crossref","unstructured":"Paidas MJ, et\u00a0al. Hemostasis and thrombosis in obstetrics and gynecology.  Hoboken, NJ:  John Wiley & Sons, 2011, p.1.","DOI":"10.1002\/9781444328332.ch1"},{"key":"bibr5-1753495X211019899","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2010.01.021"},{"key":"bibr6-1753495X211019899","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1344"},{"key":"bibr7-1753495X211019899","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21757"},{"key":"bibr8-1753495X211019899","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-06-095646"},{"key":"bibr9-1753495X211019899","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08099.x"},{"key":"bibr10-1753495X211019899","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1502950"},{"key":"bibr11-1753495X211019899","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000000248"},{"key":"bibr12-1753495X211019899","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-016-1946-x"},{"key":"bibr13-1753495X211019899","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.1707"},{"key":"bibr14-1753495X211019899","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2014.11.003"},{"key":"bibr15-1753495X211019899","unstructured":"PNH National Service. Eculizumab administration Guidelines, www.pnhleeds.co.uk\/professionals\/eculizumab-administration-guidelines (2020, accessed 3 September 2020)."},{"key":"bibr16-1753495X211019899","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2011.04.011"},{"key":"bibr17-1753495X211019899","volume-title":"Preterm labour and birth","author":"National Collaborating Centre for Women's and Children\u2019s Health (UK)","year":"2015"}],"container-title":["Obstetric Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753495X211019899","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1753495X211019899","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753495X211019899","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T09:19:31Z","timestamp":1770023971000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1753495X211019899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,20]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1177\/1753495X211019899"],"URL":"https:\/\/doi.org\/10.1177\/1753495x211019899","relation":{},"ISSN":["1753-495X","1753-4968"],"issn-type":[{"value":"1753-495X","type":"print"},{"value":"1753-4968","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,20]]}}}