{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T16:47:14Z","timestamp":1761324434925,"version":"3.38.0"},"reference-count":21,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:00:00Z","timestamp":1647993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Obstet Med"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:p> COVID-19 infection in pregnancy can cause respiratory and obstetric complications,<jats:sup> 1 <\/jats:sup> however emerging evidence on its impact in pregnancy is limited. This article aims to review data collected and analysed so far over the course of the coronavirus pandemic, that examine demographic associations, patterns of disease, severity and outcomes of COVID-19 in pregnancy in the UK. <\/jats:p><jats:p> Hospital admission, for which black and minority ethnic background and raised body mass index are risk factors, is associated with maternal mortality and admission to intensive care and is more likely in the late second or third trimester.<jats:sup> 2 <\/jats:sup> Vaccination is safe in pregnancy<jats:sup> 3 <\/jats:sup> and is protective against severe COVID-19 and admission to intensive care,<jats:sup> 4 , 5 <\/jats:sup> Maternal SARS CoV-2 is associated with a greater risk of stillbirth, preterm birth, small for gestational age (SGA) and preeclampsia.<jats:sup> 6 <\/jats:sup> Efforts to reduce the incidence of COVID-19 in pregnancy, including vaccination, are therefore likely to reduce preventable complications from this disease. <\/jats:p>","DOI":"10.1177\/1753495x221083134","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T07:40:57Z","timestamp":1648021257000},"page":"216-219","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["COVID-19 in pregnancy: A UK perspective"],"prefix":"10.1177","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5656-0221","authenticated-orcid":false,"given":"Sanaa","family":"Zayyan","sequence":"first","affiliation":[{"name":"Oxford University Hospitals NHS Foundation Trust, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Frise","sequence":"additional","affiliation":[{"name":"Fetal Maternal Medicine Unit and Department of Acute and General Medicine, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,3,23]]},"reference":[{"key":"bibr1-1753495X221083134","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2020.03.021"},{"key":"bibr2-1753495X221083134","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m2107"},{"key":"bibr3-1753495X221083134","first-page":"1","volume":"00","author":"Rottenstreich","year":"2021","journal-title":"BJOG"},{"journal-title":"MedRxiv","year":"2021","author":"Vousden","key":"bibr4-1753495X221083134"},{"key":"bibr5-1753495X221083134","unstructured":"MBRRACE-UK. Key information on COVID-19 in pregnancy infographic. 11th October 2021. (https:\/\/www.npeu.ox.ac.uk\/assets\/downloads\/MBRRACE-UK_Rapid_COVID_19_2021_-__Infographic_v10.pdf)"},{"key":"bibr6-1753495X221083134","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2021.1050"},{"key":"bibr7-1753495X221083134","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.12.033"},{"key":"bibr8-1753495X221083134","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-020-01343-9"},{"key":"bibr9-1753495X221083134","unstructured":"RCOG. Coronavirus (COVID-19) infection and pregnancy. August 2021. (https:\/\/www.rcog.org.uk\/globalassets\/documents\/guidelines\/2021-08-25-coronavirus-covid-19-infection-in-pregnancy-v14.pdf)."},{"key":"bibr10-1753495X221083134","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-022-01730-5"},{"journal-title":"Am J Obstet Gynecol","year":"2021","author":"Blakeway","key":"bibr11-1753495X221083134"},{"key":"bibr12-1753495X221083134","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30183-5"},{"key":"bibr13-1753495X221083134","unstructured":"Knight, et al. Rapid report : Learning from SARS-CoV-2-related and associated maternal deaths in the UK March-May 2020. (https:\/\/www.npeu.ox.ac.uk\/assets\/downloads\/mbrrace-uk\/reports\/MBRRACE-UK_Maternal_Report_2020_v10_FINAL.pdf)."},{"key":"bibr14-1753495X221083134","unstructured":"Public Health England. Disparities in the risk and outcomes of COVID-19.PHE, 2020. https:\/\/assets.publishing.service.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/908434\/Disparities_in_the_risk_and_outcomes_of_COVID_August_2020_update.pdf"},{"key":"bibr15-1753495X221083134","unstructured":"Knight, et al. Rapid report 2021: Learning from SARS-CoV-2-related and associated maternal deaths in the UK June 2020 \u2013 March 2021. (https:\/\/www.npeu.ox.ac.uk\/assets\/downloads\/mbrrace-uk\/reports\/MBRRACE-UK_Maternal_Report_June_2021_-_FINAL_v10.pdf)"},{"key":"bibr16-1753495X221083134","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.05.016"},{"key":"bibr17-1753495X221083134","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13306"},{"key":"bibr18-1753495X221083134","unstructured":"Knight, et al. MBRRACE-UK: Saving Lives, Improving Mothers\u2019 Care: Lessons learned to inform maternity care from the UK and Ireland Confidential Enquiries into Maternal Deaths and Morbidity 2014\u201316. 2018 (https:\/\/www.npeu.ox.ac.uk\/assets\/downloads\/mbrrace-uk\/reports\/MBRRACE-UK%20Maternal%20Report%202018%20-%20Web%20Version.pdf)."},{"key":"bibr19-1753495X221083134","unstructured":"Knight, et al. MBRRACE-UK: Saving Lives, Improving Mothers\u2019 Care: Lessons learned to inform maternity care from the UK and Ireland Confidential Enquiries into Maternal Deaths and Morbidity 2015\u201317. 2019. (https:\/\/www.npeu.ox.ac.uk\/assets\/downloads\/mbrrace-uk\/reports\/MBRRACE-UK%20Maternal%20Report%202019%20-%20WEB%20VERSION.pdf)."},{"key":"bibr20-1753495X221083134","first-page":"506","volume":"48","author":"Taylor JK","year":"2020","journal-title":"Medicine & Ethics"},{"key":"bibr21-1753495X221083134","unstructured":"ICNARC. 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