{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T10:19:27Z","timestamp":1779185967683,"version":"3.51.4"},"reference-count":17,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T00:00:00Z","timestamp":1647561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["P20 GM103652"],"award-info":[{"award-number":["P20 GM103652"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL130702"],"award-info":[{"award-number":["R01HL130702"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL157288"],"award-info":[{"award-number":["R01HL157288"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"name":"William and Mary Oh \u2013 William and Elsa Zopfi Professorship in Pediatrics for Perinatal Research"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Obstet Med"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Accumulating evidence indicates that maternal hypothalamic-pituitary-adrenal (HPA) axis activity over pregnancy differs according to maternal history of childhood maltreatment. DNA methylation of the placental 11-beta-hydroxysteroid dehydrogenase (BHSD) type 2 enzyme regulates fetal exposure to maternal cortisol, yet the association between maternal history of childhood maltreatment and methylation of placental 11BHSD type 2 has not been previously studied. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> We examined if maternal cortisol production at 11 and 32 weeks\u2019 gestation (n\u2009=\u200989) and placental methylation of the 11BHSD type 2 gene (n\u2009=\u200919) differed among pregnant women with and without histories of childhood maltreatment. Twenty-nine percent of participants reported a history of childhood maltreatment (physical\/sexual abuse). <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> Women with histories of childhood maltreatment displayed lower cortisol in early gestation, hypo-methylation of placental 11BHSD type 2, and lower levels of cord blood cortisol. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Preliminary results suggest alterations in cortisol regulation over pregnancy according to maternal history of childhood maltreatment. <\/jats:p><\/jats:sec>","DOI":"10.1177\/1753495x221087168","type":"journal-article","created":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T08:19:42Z","timestamp":1647591582000},"page":"12-16","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Maternal history of childhood maltreatment is associated with diurnal cortisol and DNA methylation of placental 11-beta-hydroxysteroid dehydrogenase type 2"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8765-7846","authenticated-orcid":false,"given":"Margaret","family":"Bublitz","sequence":"first","affiliation":[{"name":"Women\u2019s Medicine Collaborative, Miriam Hospital, Providence, RI, USA"},{"name":"Psychiatry & Human Behavior, Brown University Warren Alpert Medical School, Providence, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Kelsey","sequence":"additional","affiliation":[{"name":"Departments of Epidemiology and Pathology and Laboratory Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA"},{"name":"Center for Environmental Health and Technology, Brown University, Providence, RI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rondi","family":"Butler","sequence":"additional","affiliation":[{"name":"Center for Environmental Health and Technology, 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