{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T11:49:04Z","timestamp":1784202544516,"version":"3.55.0"},"reference-count":17,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Obstet Med"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:p> In pregnant women, low molecular weight heparin is recommended as the preferred agent for venous thromboembolism prophylaxis and treatment. Despite their widespread application, heparin-induced skin lesions are probably under-reported and under-estimated. We present a case report of a primigravida treated with low molecular weight heparin for deep vein thrombosis, who developed a delayed-type hypersensitivity reaction to enoxaparin, tinzaparin and dalteparin. As the patient was pregnant, treatment options were restricted. Tolerance was achieved with dalteparin with adjuvant administration of prednisolone. An attempt to decrease prednisolone dose triggered delayed-type hypersensitivity reaction recurrence that was solved by keeping the initial prednisolone prescription. To the best of our knowledge, there are no described cases using this approach. In cases of delayed-type hypersensitivity reaction to low molecular weight heparin during pregnancy our case suggests that switching low molecular weight heparin and adjuvant administration of prednisolone can be an option. <\/jats:p>","DOI":"10.1177\/1753495x221102709","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T08:03:54Z","timestamp":1653638634000},"page":"260-262","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Cutaneous hypersensitivity reaction to low molecular weight heparins in pregnancy, cross reactivity and prednisolone treatment: A case report"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4446-5363","authenticated-orcid":false,"given":"Susana","family":"Saraiva","sequence":"first","affiliation":[{"name":"Servi\u00e7o de Obstetr\u00edcia do Centro Hospitalar Entre o Douro e Vouga, Santa Maria da Feira, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde","family":"Martins","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Obstetr\u00edcia do Centro Hospitalar Entre o Douro e Vouga, Santa Maria da Feira, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Sereno","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Obstetr\u00edcia do Centro Hospitalar Entre o Douro e Vouga, Santa Maria da Feira, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Obstetr\u00edcia do Centro Hospitalar Entre o Douro e Vouga, Santa Maria da Feira, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusta","family":"Pinto","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Obstetr\u00edcia do Centro Hospitalar Entre o Douro e Vouga, Santa Maria da Feira, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e1tia","family":"Rasteiro","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Obstetr\u00edcia do Centro Hospitalar Entre o Douro e Vouga, Santa Maria da Feira, Portugal"},{"name":"Faculdade de Ci\u00eancias M\u00e9dicas, Universidade da Beira Interior, Covilh\u00e3, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,5,27]]},"reference":[{"key":"bibr1-1753495X221102709","doi-asserted-by":"publisher","DOI":"10.1016\/0049-3848(84)90260-3"},{"key":"bibr2-1753495X221102709","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1651102"},{"key":"bibr3-1753495X221102709","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtumed.2020.12.016"},{"key":"bibr4-1753495X221102709","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-015-1309-0"},{"key":"bibr5-1753495X221102709","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000281"},{"key":"bibr6-1753495X221102709","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01227.x"},{"key":"bibr7-1753495X221102709","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-02-0626"},{"key":"bibr8-1753495X221102709","volume-title":"clinical and research information on drug-induced liver injury"},{"key":"bibr9-1753495X221102709","doi-asserted-by":"publisher","DOI":"10.1097\/WOX.0b013e31818def58"},{"key":"bibr10-1753495X221102709","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2019-136464"},{"key":"bibr11-1753495X221102709","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.02.047"},{"key":"bibr12-1753495X221102709","doi-asserted-by":"publisher","DOI":"10.1159\/000453525"},{"key":"bibr13-1753495X221102709","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60409-7"},{"key":"bibr14-1753495X221102709","doi-asserted-by":"publisher","DOI":"10.1160\/TH06-04-0210"},{"key":"bibr15-1753495X221102709","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01932.x"},{"key":"bibr16-1753495X221102709","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018024802"},{"issue":"2","key":"bibr17-1753495X221102709","volume":"27","author":"Dempfle C-E","year":"2021","journal-title":"Clin Appl Thromb Hemost"}],"container-title":["Obstetric Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753495X221102709","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1753495X221102709","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753495X221102709","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T11:57:38Z","timestamp":1740830258000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1753495X221102709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,27]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1177\/1753495X221102709"],"URL":"https:\/\/doi.org\/10.1177\/1753495x221102709","relation":{},"ISSN":["1753-495X","1753-4968"],"issn-type":[{"value":"1753-495X","type":"print"},{"value":"1753-4968","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,27]]}}}