{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:53:21Z","timestamp":1790488401060,"version":"4.1.0"},"reference-count":28,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T00:00:00Z","timestamp":1696809600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Obstet Med"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p> Obstetric and kidney outcomes following detection of nephrotic-range proteinuria in early pregnancy have not been well described. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p> A retrospective cohort study of chronic kidney disease (CKD) in pregnancy between 2008 and 2018. Outcomes in those with nephrotic-range proteinuria before 20 weeks\u2019 gestation were compared to those without nephrotic-range proteinuria. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p> The study included 37 women with nephrotic-range proteinuria and 62 women without. Pre-pregnancy estimated glomerular filtration rate (eGFR) was similar. Nephrotic-range proteinuria was associated with higher rates of preterm (odds ratio [OR] 1.77, 95% confidence interval [CI]: 1.07\u20132.92) and early preterm delivery (OR 2.63, 95% CI: 1.12\u20136.2), and with a requirement for renal replacement therapy at 3 years post-partum (OR 10.72, 95% CI: 2.58\u201344.47). Tubulointerstitial scarring on kidney biopsy was associated with early preterm delivery and progression to advanced CKD, independent of pre-pregnancy eGFR. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p> Compared to CKD without nephrotic-range proteinuria, nephrotic-range proteinuria early in pregnancy is associated with higher rates of pre-term delivery and progression to advanced CKD. <\/jats:p><\/jats:sec>","DOI":"10.1177\/1753495x231201896","type":"journal-article","created":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T06:32:03Z","timestamp":1696919523000},"page":"96-100","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Pregnancy in women with nephrotic-range proteinuria: A retrospective cohort study"],"prefix":"10.1177","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9721-9532","authenticated-orcid":false,"given":"Shuli","family":"Svetitsky","sequence":"first","affiliation":[{"name":"Imperial College Healthcare NHS Trust Renal and Transplant Centre, Barts Health NHS Trust, London, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4603-4076","authenticated-orcid":false,"given":"Liz","family":"Lightstone","sequence":"additional","affiliation":[{"name":"Centre for Inflammatory Disease, Department of Immunology and Inflammation, Faculty of Medicine, Imperial College London, London, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Wiles","sequence":"additional","affiliation":[{"name":"Deaprtment of Maternal Medicine, Barts Health NHS Trust, London, United Kingdom of Great Britain and Northern Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,10,9]]},"reference":[{"key":"bibr1-1753495X231201896","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014050459"},{"key":"bibr2-1753495X231201896","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.09250914"},{"key":"bibr3-1753495X231201896","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.11.019"},{"key":"bibr4-1753495X231201896","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2007.03.022"},{"key":"bibr5-1753495X231201896","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199607253350402"},{"key":"bibr6-1753495X231201896","unstructured":"Official Journal of the International Society of Nephrology KDIGO 2012 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease, www.publicationethics.org (accessed 26 July 2020)."},{"key":"bibr7-1753495X231201896","first-page":"56","volume":"28","author":"Packham 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