{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:38:53Z","timestamp":1793137133928,"version":"4.5.0"},"reference-count":68,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:00:00Z","timestamp":1752710400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Obstet Med"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:p>Acute aortic dissection related to pregnancy is rare, however represented the third most common cause of pregnancy-related cardiovascular death in the 2017 UK-MBBRACE report. The majority of women with pregnancy-related aortic dissection have an underlying inherited syndromic aortopathy, though this is often not recognised until an event. Data regarding the immediate and long-term effects of pregnancy on aortic outcome are not uniform due to publication and ascertainment biases, small sample sizes, inclusion of women whose dissection was the first presentation of the underlying disease, and incompleteness of collected data. Management recommendations are based on relatively low levels of evidence, and there is some variation between society guideline recommendations. This article seeks to review the available evidence regarding pregnancy-related aortic dissection in women inherited syndromic aortopathies, highlighting the importance of pre-conception counselling, genetic testing and a multi-disciplinary team approach to management.<\/jats:p>","DOI":"10.1177\/1753495x251359834","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T06:32:42Z","timestamp":1752820362000},"page":"5-10","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Inherited aortopathies and risk of aortic dissection and aortic syndrome in pregnancy"],"prefix":"10.1177","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2111-8625","authenticated-orcid":false,"given":"Timothy","family":"Chalk","sequence":"first","affiliation":[{"name":"The Prince Charles Hospital"},{"name":"Faculty of Medicine, The University of Queensland, Herston, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kylie","family":"Burns","sequence":"additional","affiliation":[{"name":"The Prince Charles Hospital"},{"name":"Faculty of Medicine, The University of Queensland, Herston, Queensland, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9887-714X","authenticated-orcid":false,"given":"Adam","family":"Morton","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, The University of Queensland, Herston, Queensland, Australia"},{"name":"QLD Diabetes Centre, Obstetric Medicine, Mater Health, Raymond Terrace, South Brisbane, Queensland, Ausralia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,7,17]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa497"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(21)04752-5"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2021-319828"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2021.03.028"},{"key":"e_1_3_2_6_2","first-page":"58","article-title":"Clinical features and outcomes of pregnancy-related acute aortic dissection","volume":"6","author":"Braverman AC","year":"2021","unstructured":"Braverman AC, Mittauer E, Harris KM, et al. Clinical features and outcomes of pregnancy-related acute aortic dissection. JAMA Cardiol 2021; 6: 58\u201366.","journal-title":"JAMA Cardiol"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.14305"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.12.066"},{"key":"e_1_3_2_9_2","first-page":"1073","article-title":"Maternal hemodynamics and aortic diameter in normal and hypertensive pregnancies","volume":"78","author":"Easterling TR","year":"1991","unstructured":"Easterling TR, Benedetti TJ, Schmucker BC, et al. Maternal hemodynamics and aortic diameter in normal and hypertensive pregnancies. Obstet Gynecol 1991; 78: 1073\u20131077.","journal-title":"Obstet Gynecol"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.09.107"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/1753495X231156851"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2014.53"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.14797\/mdcvj.1371"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-019-05226-5"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s13167-022-00291-4"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2008.102756"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/ohn.576"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.7636"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1159\/000494328"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2016-209560"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejendo\/lvae050"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0004.2001.600507.x"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000005261"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.01.031"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00027"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-17-0430"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.122.20018"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1177\/2042018817746291"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/cen.15078"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2020-316719"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1097\/OGX.0000000000000833"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2018.08.005"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2019.05.012"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det082"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew012"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der166"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.18142"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-022-00992-1"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.10.024"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15670"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajogmf.2024.101340"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11748-012-0073-8"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055695"},{"key":"e_1_3_2_44_2","volume-title":"GeneReviews((R))","author":"Loeys BL","year":"1993","unstructured":"Loeys BL, Dietz HC, et al. Loeys-Dietz syndrome. In: Adam MP, Feldman J, Mirzaa GM (eds) GeneReviews((R)). Seattle, WA, 1993."},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1161\/circ.150.suppl_1.4143083"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000002615"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1177\/1753495X19852819"},{"key":"e_1_3_2_48_2","article-title":"ACC\/AHA guideline for the diagnosis and management of aortic disease: a report of the American Heart Association\/American College of Cardiology joint committee on clinical practice guidelines","volume":"146","author":"Isselbacher EM","year":"2022","unstructured":"Isselbacher EM, Preventza O, Hamilton Black J, 3rd, et al. ACC\/AHA guideline for the diagnosis and management of aortic disease: a report of the American Heart Association\/American College of Cardiology joint committee on clinical practice guidelines. Circulation 2022 2022; 146: e334\u2013e482.","journal-title":"Circulation 2022"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1055\/a-2072-0469"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.631"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2020.10.020"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60960-9"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1404731"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa377"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.11.005"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.08648"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.17025"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2020-239916"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1111\/1742-6723.12956"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.21037\/acs-2023-adw-0164"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijoa.2005.01.001"},{"key":"e_1_3_2_62_2","doi-asserted-by":"publisher","DOI":"10.1111\/anae.16034"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.1177\/1753495X18754577"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003446"},{"key":"e_1_3_2_65_2","first-page":"11","article-title":"Oxytocin antagonism prevents pregnancy-associated aortic dissection in a mouse model of Marfan syndrome","author":"Habashi JP","year":"2019","unstructured":"Habashi JP, MacFarlane EG, Bagirzadeh R, et al. Oxytocin antagonism prevents pregnancy-associated aortic dissection in a mouse model of Marfan syndrome. Sci Transl Med 2019: 11.","journal-title":"Sci Transl Med"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI130730"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1111\/jocs.15575"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1177\/1753495X221078447"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2020.09.624"}],"container-title":["Obstetric Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753495X251359834","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1753495X251359834","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753495X251359834","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T14:17:21Z","timestamp":1775571441000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1753495X251359834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,17]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1177\/1753495X251359834"],"URL":"https:\/\/doi.org\/10.1177\/1753495x251359834","relation":{},"ISSN":["1753-495X","1753-4968"],"issn-type":[{"value":"1753-495X","type":"print"},{"value":"1753-4968","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,17]]}}}