{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T00:49:22Z","timestamp":1769388562079,"version":"3.49.0"},"reference-count":12,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"name":"ICP Support"},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["092993\/Z\/10\/Z"],"award-info":[{"award-number":["092993\/Z\/10\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Obstet Med"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The severity of intrahepatic cholestasis of pregnancy (ICP) reflects peak maternal bile acid (BA) concentration. However, the course of the disease is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Longitudinal observational cohort study of individuals with ICP. Serial BA and alanine aminotransferase (ALT) trajectories were determined according to starting severity. Multiple logistic regression identified variables predictive of subsequent disease severity, validated using data from a randomised controlled trial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Although highly variable, BA concentrations increased across gestation (\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u2009&gt;\u20090.001). Normal ALT concentration at diagnosis predicted concurrent non-severe disease (negative predictive value 94.2% (91.6\u201396.1%)). Gestational age and BA concentration at diagnosis somewhat predicted later moderate or severe disease (BA\u2009\u2265\u200940 \u00b5mol\/L: ROCAUC 0.64 (0.58\u20130.69); BA\u2009\u2265\u2009100\u2005\u00b5mol\/L: ROCAUC 0.68 (0.62\u20130.73)), similarly in the validation cohort (ROCAUC 0.70 (0.65\u20130.76) and 0.69 (0.63\u20130.76), respectively).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>An earlier gestation and higher BA concentration at diagnosis increase the likelihood of more severe disease; however robust prediction is limited.<\/jats:p>\n                  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