{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T08:44:24Z","timestamp":1775465064156,"version":"3.50.1"},"reference-count":61,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Obstet Med"],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Mixed connective tissue disease (MCTD) is an autoimmune condition with overlapping features of lupus, systemic sclerosis, and polymyositis. Maternal\u2013fetal outcomes specific to MCTD remain poorly characterized; a scoping review was conducted.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Five databases were queried. Extracted data included demographics, antibody profiles, symptoms, treatments, and maternal\u2013fetal outcomes. Descriptive analysis was performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 269 articles, 33 met inclusion criteria, including 375 pregnancies. Common symptoms and disease manifestations included Raynaud's phenomenon, arthralgias, and sclerodactyly. Treatments included hydroxychloroquine, azathioprine, and corticosteroids. Maternal complications included interstitial lung disease (21.4%), gestational hypertension (HTN) (15.6%), chronic HTN (7.0%), pulmonary HTN (9.8%), eclampsia (1.4%), miscarriage (20.3%), preterm birth (19.6%), and stillbirth (8.1%). Fetal complications included chondrodysplasia punctata (18.2%), demise (6.5%), neonatal lupus erythematosus (3.3%), and congenital heart block (1.0%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>While most MCTD pregnancies resulted in live birth, they carry elevated maternal and perinatal risks that warrant heightened surveillance and tailored management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1753495x261427244","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T10:42:32Z","timestamp":1775040152000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Maternal and fetal outcomes in pregnancies affected by mixed connective tissue disease"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0068-6578","authenticated-orcid":false,"given":"Shannon Y.","family":"Zhou","sequence":"first","affiliation":[{"name":"University of Minnesota Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lily","family":"Holden","sequence":"additional","affiliation":[{"name":"University of Minnesota Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melody","family":"Colon","sequence":"additional","affiliation":[{"name":"University of Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7496-0465","authenticated-orcid":false,"given":"Alexandra","family":"Cregan","sequence":"additional","affiliation":[{"name":"University of Minnesota Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9419-2944","authenticated-orcid":false,"given":"Sabrina C.","family":"Burn","sequence":"additional","affiliation":[{"name":"University of Minnesota Medical School"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"e_1_3_2_2_2","unstructured":"Sapkota B Al Khalili Y. 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