{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T13:56:15Z","timestamp":1775915775516,"version":"3.50.1"},"reference-count":13,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:00:00Z","timestamp":1775692800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Obstet Med"],"abstract":"<jats:p>\n                    Jervell and Lange-Nielsen syndrome (JLNS) is a rare autosomal recessive disorder characterised by congenital sensorineural hearing loss and prolonged QT interval, predisposing to ventricular arrhythmia and sudden cardiac death. We report a 32-year-old woman with congenital deafness and recurrent syncope since childhood, diagnosed with JLNS due to a homozygous\n                    <jats:italic toggle=\"yes\">KCNQ1<\/jats:italic>\n                    exon 14 (c.1716-1719del) variant. She had an implantable cardioverter-defibrillator and was maintained on propranolol. During pregnancy, she developed fetal growth restriction and delivered a healthy neonate vaginally under continuous cardiac monitoring. Both mother and baby recovered uneventfully. This case emphasises the importance of genetic confirmation, multidisciplinary care, and vigilant peripartum monitoring in optimising outcomes for pregnancies complicated by JLNS.\n                  <\/jats:p>","DOI":"10.1177\/1753495x261439230","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T14:06:03Z","timestamp":1775743563000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Pregnant woman with Jervell and Lange-Nielsen syndrome: a case report"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5500-6109","authenticated-orcid":false,"given":"Sivaranjani","family":"P","sequence":"first","affiliation":[{"name":"Jawaharlal Institute of Medical Education and Research"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayalakshmi","family":"Durairaj","sequence":"additional","affiliation":[{"name":"Jawaharlal Institute of Medical Education and Research"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kubera N","family":"S","sequence":"additional","affiliation":[{"name":"Jawaharlal Institute of Medical Education and Research"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashwini Vishalakshi","family":"L","sequence":"additional","affiliation":[{"name":"Jawaharlal Institute of Medical Education and Research"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,9]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(57)90079-0"},{"key":"e_1_3_2_3_2","volume-title":"GeneReviews\u00ae [Internet]","author":"Tranebj\u00e6rg L","year":"2002","unstructured":"Tranebj\u00e6rg L, Samson RA, Green GE. Jervell and Lange-Nielsen syndrome. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A (eds) GeneReviews\u00ae [Internet]. Seattle, WA: University of Washington, 2002."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.592899"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac262"},{"key":"e_1_3_2_6_2","article-title":"Macro T-wave alternans in Jervell and Lange-Nielsen syndrome","volume":"15","author":"Das D","year":"2023","unstructured":"Das D, Mohanty S. Macro T-wave alternans in Jervell and Lange-Nielsen syndrome. Cureus 2023; 15: e34762.","journal-title":"Cureus"},{"key":"e_1_3_2_7_2","unstructured":"Woosley RL Heise CW Gallo T et al. QT drugs list and drug-drug interactions database (CredibleMeds)."},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2016.09.012"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.579525"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2016.46.6.747"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac262"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951121003413"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2022.05.001"},{"key":"e_1_3_2_14_2","first-page":"100964","article-title":"A practical approach to diagnosing and managing long QT syndrome","volume":"6","author":"Vyas H","year":"2024","unstructured":"Vyas H, Hejlik J, Ackerman MJA practical approach to diagnosing and managing long QT syndrome. Am J ObstetGynecol MFM 2024; 6: 100964.","journal-title":"Am J ObstetGynecol MFM"}],"container-title":["Obstetric Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753495X261439230","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1753495X261439230","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753495X261439230","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T13:16:49Z","timestamp":1775913409000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1753495X261439230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,9]]},"references-count":13,"alternative-id":["10.1177\/1753495X261439230"],"URL":"https:\/\/doi.org\/10.1177\/1753495x261439230","relation":{},"ISSN":["1753-495X","1753-4968"],"issn-type":[{"value":"1753-495X","type":"print"},{"value":"1753-4968","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,9]]},"article-number":"1753495X261439230"}}