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Methanol freely crosses the placenta, and fetal metabolism of formate is limited, making the fetus particularly susceptible to hypoxic and metabolic injury. Clinical recognition is challenging due to nonspecific early symptoms, and prompt maternal stabilization with antidotal therapy, folate supplementation, and hemodialysis is critical to prevent irreversible fetal damage. Preventive strategies require a multidimensional approach, including public health education, regulatory oversight of methanol-containing products, and standardized clinical protocols for early recognition and treatment. Addressing social determinants of health and ensuring equitable access to maternal care are essential to mitigate risk among vulnerable populations. This review integrates biomedical, obstetric, and public health perspectives to provide a comprehensive overview of maternal\u2013fetal toxicity, clinical presentation, diagnosis, management, and perinatal outcomes.<\/jats:p>","DOI":"10.1177\/1753495x261439673","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T11:52:36Z","timestamp":1775476356000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Methanol poisoning in pregnancy: A hidden threat in obstetric care"],"prefix":"10.1177","author":[{"given":"Ant\u00f4nio","family":"Braga","sequence":"first","affiliation":[{"name":"Federal University of Rio de Janeiro (UFRJ)"},{"name":"Department of Maternal and Child Health, School of Medicine, Fluminense Federal University (UFF), Niter\u00f3i, RJ, Brazil"},{"name":"Postgraduate Program in Applied Health Sciences, University of Vassouras, Vassouras, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo Yano","family":"Callado","sequence":"additional","affiliation":[{"name":"Albert Einstein Israelite Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela","family":"Paiva","sequence":"additional","affiliation":[{"name":"Federal University of Rio de Janeiro (UFRJ)"},{"name":"Department of Maternal and Child Health, School of Medicine, Fluminense Federal University (UFF), Niter\u00f3i, RJ, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Rezende-Filho","sequence":"additional","affiliation":[{"name":"Federal University of Rio de Janeiro (UFRJ)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6145-2532","authenticated-orcid":false,"given":"Edward","family":"Araujo J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Paulista School of Medicine, Federal University of S\u00e3o Paulo (EPM-UNIFESP), S\u00e3o Paulo, SP, Brazil"},{"name":"Discipline of Woman Health, Municipal University of S\u00e3o Caetano Do Sul (USCS), S\u00e3o Caetano Do Sul, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu13103452"},{"key":"e_1_3_2_3_2","unstructured":"Minist\u00e9rio da Sa\u00fade (Brasil). 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