{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T07:57:25Z","timestamp":1781337445223,"version":"3.54.1"},"reference-count":31,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:00:00Z","timestamp":1781049600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Obstet Med"],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Renal tubular acidosis (RTA) is a disorder of renal acid\u2013base regulation causing normal anion gap metabolic acidosis. Among its three types, distal RTA (dRTA) is the most common form.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective case series included pregnancies complicated by RTA managed at Fernandez Hospital, Hyderabad, India, between 2008 and 2024. Maternal and perinatal outcomes data were obtained from medical records.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 133,542 deliveries, 19 pregnancies were complicated by RTA, giving an incidence of 0.014%. All cases were Type I dRTA, with 84% secondary to connective tissue disorders, predominantly Sj\u00f6gren's syndrome. Recurrent hypokalaemic periodic paralysis was the most common complication. With early diagnosis and meticulous metabolic correction, most women achieved term deliveries with favourable maternal and neonatal outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Renal tubular acidosis in pregnancy may worsen due to physiological changes. Untreated disease poses risks from chronic acidosis and electrolyte imbalance. Early recognition and multidisciplinary management are crucial for optimal outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/1753495x261456364","type":"journal-article","created":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T09:10:44Z","timestamp":1781082644000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Renal tubular acidosis (RTA) complicated pregnancies: A tertiary centre experience"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7230-9627","authenticated-orcid":false,"given":"Arati","family":"Singh","sequence":"first","affiliation":[{"name":"Fernandez Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarakeswari","family":"Surapaneni","sequence":"additional","affiliation":[{"name":"Fernandez Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemamalini","family":"Vadlamani","sequence":"additional","affiliation":[{"name":"Fernandez Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,6,10]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"1342135","article-title":"A rare case of transient proximal renal tubular acidosis in pregnancy","volume":"2017","author":"Narcisse D","year":"2017","unstructured":"Narcisse D, Agarwal M, Kumar A. A rare case of transient proximal renal tubular acidosis in pregnancy. Case Rep Nephrol 2017; 2017: 1342135.","journal-title":"Case Rep Nephrol"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v11.i25.5988"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000094942"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-10006"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.5348\/100083Z08MS2021CR"},{"key":"e_1_3_3_7_2","unstructured":"Casanova C Mart\u00ednez AI Subir\u00e1 J et al. Management of distal renal tubular acidosis (RTA) or RTA type I in pregnancy. Two case reports."},{"key":"e_1_3_3_8_2","first-page":"1127","article-title":"Pregnancy predisposes to rhabdomyolysis due to hypokalemia","volume":"21","author":"Muthukrishnan J","year":"2010","unstructured":"Muthukrishnan J. Pregnancy predisposes to rhabdomyolysis due to hypokalemia. Saudi J Kidney Dis Transpl 2010; 21: 1127\u20138.","journal-title":"Saudi J Kidney Dis Transpl"},{"key":"e_1_3_3_9_2","first-page":"763","article-title":"Systemic lupus erythematosus and hypothyroidism","volume":"31","author":"Fikri Benbrahim O","year":"2011","unstructured":"Fikri Benbrahim O, Cazalla Cadenas F, Valent\u00edn Mart\u00edn A, et al. Systemic lupus erythematosus and hypothyroidism. Nefrologia 2011; 31: 763\u20134.","journal-title":"Nefrologia"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1258\/om.2011.110041"},{"key":"e_1_3_3_11_2","article-title":"Hypokalemia-Induced rhabdomyolysis as a result of distal renal tubular acidosis in a pregnant woman: a case report and literature review","volume":"2015","author":"Srisuttayasathien M","year":"2015","unstructured":"Srisuttayasathien M. Hypokalemia-Induced rhabdomyolysis as a result of distal renal tubular acidosis in a pregnant woman: a case report and literature review. 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A rare case of Renal Tubular Acidosis (type 1 distal) in pregnancy."},{"key":"e_1_3_3_18_2","article-title":"Renal tubular acidosis in the postpartum period: a case report and literature review","volume":"2021","author":"Duran CE","year":"2021","unstructured":"Duran CE, Estacio M, Lozano F, et al. Renal tubular acidosis in the postpartum period: a case report and literature review. Case Rep Nephrol 2021; 2021: Article ID 6693013.","journal-title":"Case Rep Nephrol"},{"key":"e_1_3_3_19_2","article-title":"Primary renal tubular acidosis during pregnancy, what about the perinatal prognosis?","author":"Van Laethem J","unstructured":"Van Laethem J, Seyler L, Tonnelier A. Primary renal tubular acidosis during pregnancy, what about the perinatal prognosis? Nefrolog\u00eda [Internet] 2024 [cited 2024 Dec 28], https:\/\/www.sciencedirect.com\/science\/article\/pii\/S021169952400119X.","journal-title":"Nefrolog\u00eda [Internet]"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2025-266855"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.5662\/wjm.v5.i2.55"},{"key":"e_1_3_3_22_2","unstructured":"Mustaqeem R Arif A. Renal Tubular Acidosis. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 [cited 2025 Jan 20] http:\/\/www.ncbi.nlm.nih.gov\/books\/NBK519044\/."},{"key":"e_1_3_3_23_2","article-title":"A case report of paralysis and respiratory difficulty in a patient with a recent history of complicated pregnancy \u2013 an uncommon expression of distal renal tubular acidosis","volume":"15","author":"Kumari P","year":"2023","unstructured":"Kumari P, Jitidhar F, Kiran F, et al. 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