{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:07:57Z","timestamp":1789808877447,"version":"4.0.1"},"reference-count":24,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Obstet Med"],"abstract":"<jats:p>Factor XIII (FXIII) deficiency is a rare inherited coagulation disorder that can cause recurrent pregnancy loss, placental complications and postpartum haemorrhage due to loss of clot stabilization. Managing pregnancy in affected women is challenging especially in low-resource settings where availability of FXIII concentrates and investigations for monitoring are limited. We report a case of severe congenital FXIII deficiency in a woman with four recurrent first-trimester pregnancy losses for whom diagnosis was confirmed by clot solubility testing and quantitative FXIII assays. Due to financial constraints, prophylactic cryoprecipitate was given instead of Factor XIII concentrate. Even in the absence of serial quantitative factor XIII levels, with multidisciplinary care, structured antenatal surveillance and planned peripartum FXIII replacement using cryoprecipitate, she could achieve two successful term deliveries without major maternal or neonatal bleeding complications. Thus, cryoprecipitate is an effective alternative when FXIII concentrate is unavailable.<\/jats:p>","DOI":"10.1177\/1753495x261489465","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:46:37Z","timestamp":1789609597000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Severe factor XIII deficiency in pregnancy: A case report"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8136-5502","authenticated-orcid":false,"given":"Kamakshi","family":"Mam","sequence":"first","affiliation":[{"name":"All India Institute of Medical Sciences (AIIMS)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avantika","family":"Gupta","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences (AIIMS)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayushi","family":"Sethi","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences (AIIMS)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Dhingra","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences (AIIMS)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun Kumar","family":"Dora","sequence":"additional","affiliation":[{"name":"All India Institute of Medical Sciences (AIIMS)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01857.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01648.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1572326"},{"key":"e_1_3_2_5_2","first-page":"446","article-title":"Congenital factor XIII deficiency and recurrent pregnancy loss","volume":"82","author":"Asahina T","year":"2004","unstructured":"Asahina T, Kobayashi T, Takeuchi K, et al. Congenital factor XIII deficiency and recurrent pregnancy loss. Fertil Steril 2004; 82: 446\u2013448.","journal-title":"Fertil Steril"},{"key":"e_1_3_2_6_2","first-page":"301","article-title":"Mechanisms of normal and abnormal placentation","volume":"38","author":"Lockwood CJ.","year":"2014","unstructured":"Lockwood CJ. Mechanisms of normal and abnormal placentation. Semin Perinatol 2014; 38: 301\u2013312.","journal-title":"Semin Perinatol"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2007.09.003"},{"key":"e_1_3_2_8_2","first-page":"574","article-title":"Physiopathology and regulation of factor XIII","volume":"109","author":"Ichinose A.","year":"2013","unstructured":"Ichinose A. Physiopathology and regulation of factor XIII. Thromb Haemost 2013; 109: 574\u2013585.","journal-title":"Thromb Haemost"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02841.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.02021.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-06-820738"},{"key":"e_1_3_2_12_2","first-page":"633","article-title":"Bleeding disorders in pregnancy","volume":"115","author":"James AH.","year":"2010","unstructured":"James AH. Bleeding disorders in pregnancy. Obstet Gynecol 2010; 115: 633\u2013646.","journal-title":"Obstet Gynecol"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.4103\/ipcares.ipcares_74_22"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1053\/plac.1999.0489"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389450054545953"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-38832"},{"key":"e_1_3_2_17_2","first-page":"37","article-title":"Studies on the role of adhesive proteins in maintaining pregnancy","volume":"50","author":"Asahina T","year":"1998","unstructured":"Asahina T, Kobayashi T, Okada Y, et al. Studies on the role of adhesive proteins in maintaining pregnancy. Horm Res 1998; 50: 37\u201345. PMID 9721590.","journal-title":"Horm Res"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-02-0595"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2008.01857.x"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.70181"},{"key":"e_1_3_2_21_2","article-title":"on behalf of the Royal College of Obstetricians and Gynaecologists. Management of inherited bleeding disorders in pregnancy. Green-top Guideline","volume":"124","author":"Pavord S","year":"2017","unstructured":"Pavord S, Rayment R, Madan B, et al. on behalf of the Royal College of Obstetricians and Gynaecologists. Management of inherited bleeding disorders in pregnancy. Green-top Guideline. BJOG 2017; 124: e194\u2013e263.","journal-title":"BJOG"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.46989\/001c.155180"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/hae.12259"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/10760296211051714"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ogx.0000259176.03156.2b"}],"container-title":["Obstetric Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753495X261489465","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1753495X261489465","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753495X261489465","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T08:17:30Z","timestamp":1789805850000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1753495X261489465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,16]]},"references-count":24,"alternative-id":["10.1177\/1753495X261489465"],"URL":"https:\/\/doi.org\/10.1177\/1753495x261489465","relation":{},"ISSN":["1753-495X","1753-4968"],"issn-type":[{"value":"1753-495X","type":"print"},{"value":"1753-4968","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,16]]},"article-number":"1753495X261489465"}}