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The prevalence of obesity is still continuing to increase dramatically. Overweight and obese people carry a higher risk for a variety of cardiovascular diseases including hypertension, coronary heart disease, stroke and peripheral occlusive artery disease. Weight loss is considered to be the initial step which helps to prevent or to control the clinical consequences of obesity. In a great number of patients who are not able to reduce weight by means of non-pharmacological measures, drug therapy can assist in reaching the weight management targets. Drug treatment should only be considered as part of a systematic weight management program including dietary and lifestyle changes. This review summarizes current pharmacotherapeutic concepts for the treatment of obesity in adults focusing on efficacy and safety of anti-obesity drugs. <\/jats:p>","DOI":"10.1177\/1753944708098226","type":"journal-article","created":{"date-parts":[[2008,11,29]],"date-time":"2008-11-29T01:34:46Z","timestamp":1227922486000},"page":"75-90","source":"Crossref","is-referenced-by-count":20,"title":["Current pharmacotherapeutic concepts for the treatment of obesity in adults"],"prefix":"10.1177","volume":"3","author":[{"given":"Evgeny","family":"Idelevich","sequence":"first","affiliation":[{"name":"Institute of Clinical Pharmacology, Medical Faculty, Technical University of Dresden, Dresden, Germany,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilhelm","family":"Kirch","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pharmacology, Medical Faculty, Technical University of Dresden, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Schindler","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pharmacology, Medical Faculty, Technical University of Dresden, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,2,1]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/74.5.579"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.9.994"},{"key":"atypb3","first-page":"17","volume":"1","author":"Astrup, A.","year":"2000","journal-title":"ObesRev"},{"key":"atypb4","doi-asserted-by":"publisher","DOI":"10.1124\/mol.63.4.908"},{"key":"atypb5","doi-asserted-by":"publisher","DOI":"10.1124\/mi.8.2.6"},{"key":"atypb6","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-865077"},{"key":"atypb7","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2004.05.017"},{"key":"atypb8","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802752"},{"key":"atypb9","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.03.053"},{"key":"atypb10","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1111\/j.1742-1241.2002.tb11307.x","volume":"56","author":"Broom, I.","year":"2002","journal-title":"Int J Clin Pract"},{"key":"atypb11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2007.00332.x"},{"key":"atypb12","first-page":"1061","volume":"46","author":"Centers for Disease Control and Prevention.","year":"1997","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"atypb13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61721-8"},{"volume-title":"Atherosclerosis Underlying Development assessed by Intima-media Thickness in patients On Rimonabant (AUDITOR)","year":"2008","author":"Clinicaltrials.gov","key":"atypb14"},{"volume-title":"Comprehensive Rimonabant Evaluation Study of Cardiovascular Endpoints and Outcomes (CRESCENDO)","year":"2008","author":"Clinicaltrials.gov","key":"atypb15"},{"key":"atypb16","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199708283370901"},{"key":"atypb17","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD006162.pub2"},{"key":"atypb18","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.3.235"},{"key":"atypb19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa044537"},{"key":"atypb20","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1495"},{"key":"atypb21","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2006.09.010"},{"key":"atypb22","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802982"},{"journal-title":"Press Release. 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