{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T05:41:20Z","timestamp":1740894080571,"version":"3.38.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2009,11,9]],"date-time":"2009-11-09T00:00:00Z","timestamp":1257724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Therapeutic Advances in Cardiovascular Disease"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:p> Background: Dyspnea is a common symptom in a patient with valvular heart disease. The mechanism underlying this is still uncertain. <\/jats:p><jats:p> Methods: We prospectively studied 20 patients with rheumatic mitral valve stenosis who were candidates for percutaneous balloon mitral valvotomy. Assessment of airway hyper-reactivity by histamine challenge test was done on all patients at baseline and at 1 week after the procedure. The provocative concentration of histamine solution required producing a 20% fall in forced expiratory volume in 1 second (FEV<jats:sub> 1<\/jats:sub>) (PC20) was recorded as a measure of airway hyper-reactivity. The severity of dyspnea in study subjects was also studied by the 6-minute-walk test and visual analog scale. <\/jats:p><jats:p> Results: After balloon valvotomy, a significant improvement was seen in the six minute walking distance (219\u00b130.15 to 237.55\u00b132.25; p &lt; 0.001), visual analog scale as a measure of dyspnea (60.95\u00b112.16 to 44.4\u00b113.71; p &lt; 0.001) and airway hyper-reactivity (PC20; 5.69\u00b16.01 mg\/ml to 10.16\u00b17.93; p &lt; 0.001). <\/jats:p><jats:p> Conclusions: Improvement in dyspnea in mitral stenosis after balloon valvotomy is associated with significant improvement in airway hyper-reactivity. <\/jats:p>","DOI":"10.1177\/1753944709341303","type":"journal-article","created":{"date-parts":[[2009,11,10]],"date-time":"2009-11-10T01:26:06Z","timestamp":1257816366000},"page":"423-427","source":"Crossref","is-referenced-by-count":0,"title":["Airway hyper-reactivity in rheumatic mitral stenosis improves after balloon valvotomy"],"prefix":"10.1177","volume":"3","author":[{"given":"Chandrasekar","family":"Palaniswamy","sequence":"first","affiliation":[{"name":"Department of Medicine, New York Medical College, Valhalla, NY, USA,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhana R.","family":"Selvaraj","sequence":"additional","affiliation":[{"name":"Department of Radiology, Baylor College of Medicine, Houston, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randeep","family":"Guleria","sequence":"additional","affiliation":[{"name":"Department of Medicine, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anant","family":"Mohan","sequence":"additional","affiliation":[{"name":"Department of Medicine, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajiv","family":"Narang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2009,11,9]]},"reference":[{"key":"atypb1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.166.1.at1102"},{"key":"atypb2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198905183202005"},{"key":"atypb3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1164\/ajrccm.161.1.ats11-99","volume":"161","author":"Crapo, R.O.","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"atypb4","first-page":"545","volume":"8","author":"Freedman, B.J.","year":"1972","journal-title":"Bull Physiopathol 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