{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T19:48:32Z","timestamp":1771616912981,"version":"3.50.1"},"reference-count":62,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2011,9,5]],"date-time":"2011-09-05T00:00:00Z","timestamp":1315180800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Cardiovascular Disease"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:p> Although low-density lipoprotein cholesterol (LDL-C) lowering represents the mainstay of current lipid treatment, high-density lipoprotein cholesterol (HDL-C) has generated increasing interest as a secondary therapeutic target because of strong evidence that serum HDL-C concentration is inversely associated with coronary heart disease risk. Niacin is a lipid-altering drug that has been used to lower cholesterol since the 1950s. In addition to its LDL-C-lowering effects, niacin is the most effective agent currently available for raising HDL-C. Despite its long history as a lipid-altering drug, only limited data are available regarding its clinical benefit alone and in combination with other agents, and the majority of studies investigating its impact on clinical outcomes are from the pre-statin area. Several studies have demonstrated a beneficial effect of treatment with niacin in combination with statin therapy on surrogate cardiovascular markers (e.g. carotid intima-media thickness). However, the clinical significance of these surrogate markers has been questioned. Two large randomized trials will address whether niacin\u2013statin combination therapy is an appropriate therapeutic alternative to statin monotherapy. <\/jats:p>","DOI":"10.1177\/1753944711419197","type":"journal-article","created":{"date-parts":[[2011,9,6]],"date-time":"2011-09-06T00:46:22Z","timestamp":1315269982000},"page":"227-240","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":21,"title":["The facts behind niacin"],"prefix":"10.1177","volume":"5","author":[{"given":"Willibald","family":"Hochholzer","sequence":"first","affiliation":[{"name":"TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David D.","family":"Berg","sequence":"additional","affiliation":[{"name":"TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert P.","family":"Giugliano","sequence":"additional","affiliation":[{"name":"TIMI Study Group, 350 Longwood Ave., First Floor, Boston, MA 02115, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2011,9,5]]},"reference":[{"key":"bibr1-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2010.12.007"},{"key":"bibr2-1753944711419197","doi-asserted-by":"publisher","DOI":"10.2174\/138955710791185046"},{"key":"bibr3-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(55)90070-9"},{"key":"bibr4-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60310-8"},{"key":"bibr5-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61350-5"},{"key":"bibr6-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1987.03390230069027"},{"key":"bibr7-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/sul043"},{"key":"bibr8-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)00039-3"},{"key":"bibr9-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011090"},{"key":"bibr10-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199011083231901"},{"key":"bibr11-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(86)80293-5"},{"key":"bibr12-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040583"},{"key":"bibr13-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)00731-0"},{"key":"bibr14-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1989.tb01393.x"},{"key":"bibr15-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1111\/j.0954-6820.1988.tb15891.x"},{"key":"bibr16-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1990.03450230049028"},{"key":"bibr17-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1975.03240160024021"},{"key":"bibr18-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.05.059"},{"key":"bibr19-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.20.1615"},{"key":"bibr20-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2011.547480"},{"key":"bibr21-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M300403-JLR200"},{"key":"bibr22-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1016\/S0828-282X(09)70715-9"},{"key":"bibr23-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)80185-5"},{"key":"bibr24-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm316"},{"key":"bibr25-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)34737-4"},{"key":"bibr26-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.162.14.1568"},{"key":"bibr27-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.11.018"},{"key":"bibr28-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.160.8.1177"},{"key":"bibr29-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)00448-2"},{"key":"bibr30-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09327-3"},{"key":"bibr31-1753944711419197","first-page":"183","volume":"6","author":"Hussein A.A.","year":"2010","journal-title":"Ther Clin Risk Manag"},{"key":"bibr32-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1994.00420140051007"},{"key":"bibr33-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.17.10.2020"},{"key":"bibr34-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908123410707"},{"key":"bibr35-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.06.036"},{"key":"bibr36-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61778-4"},{"key":"bibr37-1753944711419197","first-page":"2545","volume":"252","author":"Lipid Research Clinics Program","year":"1984","journal-title":"JAMA"},{"key":"bibr38-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199811053391902"},{"key":"bibr39-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1988.00380110121025"},{"key":"bibr40-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2008.01938.x"},{"key":"bibr41-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.02.047"},{"key":"bibr42-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1038\/nature01250"},{"key":"bibr43-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1908"},{"key":"bibr44-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.01.008"},{"key":"bibr45-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2486"},{"key":"bibr46-1753944711419197","unstructured":"National Heart Lung and Blood Institute (2011) http:\/\/public.nhlbi.nih.gov\/newsroom\/home\/GetPressRelease.aspx?id=2792. Accessed May 27, 2011."},{"key":"bibr47-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199901073400103"},{"key":"bibr48-1753944711419197","doi-asserted-by":"crossref","unstructured":"Polak, J.F., Pencina, M.J., Pencina, K.M., O'donnell, C.J., Wolf, P.A., and D'agostino, R.B., Sr. (2011) Carotid-Wall Intima-Media Thickness and Cardiovascular Events. The New England journal of medicine 365: 213\u2013221.","DOI":"10.1056\/NEJMoa1012592"},{"key":"bibr49-1753944711419197","first-page":"1383","volume":"344","author":"Scandinavian Simvastatin Survival Study Group","year":"1994","journal-title":"Lancet"},{"key":"bibr50-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199511163332001"},{"key":"bibr51-1753944711419197","doi-asserted-by":"crossref","first-page":"S376","DOI":"10.1161\/CIRCULATIONAHA.108.820720","volume":"120","author":"Sibley C.T.","year":"2009","journal-title":"Circulation"},{"key":"bibr52-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.110.959247"},{"key":"bibr53-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1986.03380200061022"},{"key":"bibr54-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000148955.19792.8D"},{"key":"bibr55-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907569"},{"key":"bibr56-1753944711419197","unstructured":"US Food and Drug Administration (FDA): http:\/\/www.fda.gov\/Drugs\/DrugSafety\/ucm256581.htm. Accessed June 23, 2011."},{"key":"bibr57-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.171363"},{"key":"bibr58-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1994.00420010101012"},{"key":"bibr59-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R001610"},{"key":"bibr60-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.18.1837"},{"key":"bibr61-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1159\/000242999"},{"key":"bibr62-1753944711419197","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.99.15.1959"}],"container-title":["Therapeutic Advances in Cardiovascular Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753944711419197","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1753944711419197","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753944711419197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T09:37:08Z","timestamp":1740821828000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1753944711419197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,9,5]]},"references-count":62,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["10.1177\/1753944711419197"],"URL":"https:\/\/doi.org\/10.1177\/1753944711419197","relation":{},"ISSN":["1753-9447","1753-9455"],"issn-type":[{"value":"1753-9447","type":"print"},{"value":"1753-9455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,9,5]]}}}