{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T06:06:40Z","timestamp":1740809200860,"version":"3.38.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2016,12,30]],"date-time":"2016-12-30T00:00:00Z","timestamp":1483056000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Cardiovascular Disease"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> To determine whether patients who were newly prescribed antihypertensive therapy after the Eighth Joint National Committee (JNC 8) update were treated to a relaxed systolic blood pressure (SBP) goal compared with patients treated before the update. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> A retrospective cohort study approved by the Colorado Multiple Institutional Review Board. Patients aged 60\u201379 years, without diabetes or chronic kidney disease (CKD), newly treated for hypertension at a University of Colorado primary care clinics were included. The mean first-achieved and last-stable SBPs of patients newly prescribed antihypertensive medications from 1 January 2012 to 31 December 31 2013 (before cohort) were compared with patients newly prescribed antihypertensive therapy from 1 January 2014 to 1 October 2015 (after cohort). The mean number of antihypertensive medications at first-achieved SBP, the time to first-achieved SBP, and the class of initial antihypertensive medications were also evaluated. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> A total of 128 patients were included, 64 patients in each cohort. The coprimary outcome of first-achieved mean SBP did not differ between the groups (131.3 mmHg versus 130.2 mmHg; p = 0.65). Last-stable mean SBP values were also similar between the groups (130.2 mmHg versus 129.5 mmHg; p = 0.74). Angiotensin converting enzyme inhibitors (ACE-I) were the most frequently initiated antihypertensive agent in both cohorts (43.8% versus 48.4%; p = 0.72). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p> Our findings suggest that the JNC 8 recommendations did not alter SBP goals among patients aged 60\u201379 years newly treated for hypertension at University of Colorado primary care clinics. <\/jats:p><\/jats:sec>","DOI":"10.1177\/1753944716684463","type":"journal-article","created":{"date-parts":[[2017,1,21]],"date-time":"2017-01-21T16:50:43Z","timestamp":1485017443000},"page":"63-71","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of achieved systolic blood pressure in newly treated hypertensive patients aged 60\u201379 years before and after Eighth Joint National Committee recommendations"],"prefix":"10.1177","volume":"11","author":[{"given":"Michael S.","family":"Kelly","sequence":"first","affiliation":[{"name":"Chapman University School of Pharmacy, Irvine, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph J.","family":"Saseen","sequence":"additional","affiliation":[{"name":"Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, CO, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel C.","family":"Marrs","sequence":"additional","affiliation":[{"name":"Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, 12850 E. Montview Blvd., Room V20-2128, Aurora, CO 80045, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,12,30]]},"reference":[{"key":"bibr1-1753944716684463","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0801369"},{"key":"bibr2-1753944716684463","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.09.022"},{"key":"bibr3-1753944716684463","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.07.013"},{"key":"bibr4-1753944716684463","doi-asserted-by":"publisher","DOI":"10.1177\/1753944715621000"},{"key":"bibr5-1753944716684463","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.284427"},{"key":"bibr6-1753944716684463","doi-asserted-by":"publisher","DOI":"10.1291\/hypres.31.2115"},{"key":"bibr7-1753944716684463","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.06.014"},{"key":"bibr8-1753944716684463","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2016.02.066"},{"key":"bibr9-1753944716684463","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht151"},{"key":"bibr10-1753944716684463","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.830299"},{"key":"bibr11-1753944716684463","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.05560"},{"key":"bibr12-1753944716684463","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000366"},{"key":"bibr13-1753944716684463","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.2531"},{"key":"bibr14-1753944716684463","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.109.146035"},{"key":"bibr15-1753944716684463","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03460240051027"},{"key":"bibr16-1753944716684463","doi-asserted-by":"publisher","DOI":"10.7326\/M15-2223"},{"key":"bibr17-1753944716684463","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)05381-6"},{"key":"bibr18-1753944716684463","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12644"},{"key":"bibr19-1753944716684463","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000065"},{"key":"bibr20-1753944716684463","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.7050"},{"key":"bibr21-1753944716684463","doi-asserted-by":"publisher","DOI":"10.7326\/M13-2981"},{"key":"bibr22-1753944716684463","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1511939"}],"container-title":["Therapeutic Advances in Cardiovascular Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753944716684463","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1753944716684463","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753944716684463","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T01:16:33Z","timestamp":1740791793000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1753944716684463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,30]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,2]]}},"alternative-id":["10.1177\/1753944716684463"],"URL":"https:\/\/doi.org\/10.1177\/1753944716684463","relation":{},"ISSN":["1753-9447","1753-9455"],"issn-type":[{"type":"print","value":"1753-9447"},{"type":"electronic","value":"1753-9455"}],"subject":[],"published":{"date-parts":[[2016,12,30]]}}}