{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:49:02Z","timestamp":1765079342974,"version":"3.38.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"9","license":[{"start":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T00:00:00Z","timestamp":1499126400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Cardiovascular Disease"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Clopidogrel is by far the most prescribed platelet adenosine diphosphate (ADP) antagonist in Puerto Rico despite the advent of newer agents (prasugrel and ticagrelor). Given the paucity of data on clopidogrel responsiveness in Hispanics, we sought to determine the association between clinical characteristics and platelet reactivity in Puerto Rican patients on clopidogrel therapy. <\/jats:p><\/jats:sec><jats:sec><jats:title>Study population:<\/jats:title><jats:p> A total of 100 Puerto Rican patients on clopidogrel therapy were enrolled and allocated into two groups: Group I, without high on-treatment platelet reactivity (HTPR); and Group II, with HTPR. Platelet function was measured ex vivo using the VerifyNow\u00ae P2Y12 assay. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> The cohort was comprised of Hispanic patients with coronary artery disease (57%), peripheral artery disease (32%), carotid artery stenosis (7%), cerebral artery aneurysm (2%), and stroke (2%). Mean platelet reactivity was 200 \u00b1 61 P2Y12 reaction units (PRUs) (range: 8\u2013324), and 35% of patients had HTPR (PRUs \u2a7e 230). Multivariable logistic regression analysis determined that diabetes mellitus (DM) [odds ratio (OR) = 3.27; 95% confidence interval (CI): 1.20\u20138.96], use of proton-pump inhibitors (PPIs) (OR = 3.60; 95% CI: 1.09\u201311.82), and calcium channel blockers (CCBs) (OR = 3.10; 95% CI: 1.09\u20138.83) were independent predictors of HTPR ( p &lt; 0.05) after adjusting for other clinical variables. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p> In a sample of 100 Puerto Rican Hispanic patients on clopidogrel, 35% had HTPR. Furthermore, DM, PPIs and CCBs predicted HTPR. Clinical outcome data are needed to identify appropriate PRU thresholds for risk prediction in the Puerto Rican population. <\/jats:p><\/jats:sec>","DOI":"10.1177\/1753944717718718","type":"journal-article","created":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T17:29:08Z","timestamp":1499794148000},"page":"235-241","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical determinants of clopidogrel responsiveness in a heterogeneous cohort of Puerto Rican Hispanics"],"prefix":"10.1177","volume":"11","author":[{"given":"Dagmar F.","family":"Hernandez-Suarez","sequence":"first","affiliation":[{"name":"ORCID ID: 0000-0003-1850-9078, University of Puerto Rico School of Medicine, Medical Sciences Building, PO Box 365067, San Juan, 00936-5067, Puerto Rico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stuart A.","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew I.","family":"Tomey","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine Division, Icahn School of Medicine at Mount Sinai, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle","family":"Melin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel","family":"Lopez-Candales","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine Division, University of Puerto Rico School of Medicine, San Juan, Puerto Rico, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte E.","family":"Buckley","sequence":"additional","affiliation":[{"name":"University of Michigan College of Pharmacy, Ann Arbor, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Duconge","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Department, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2017,7,4]]},"reference":[{"key":"bibr1-1753944717718718","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.78a.10145"},{"key":"bibr2-1753944717718718","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.075242"},{"key":"bibr3-1753944717718718","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0808227"},{"key":"bibr4-1753944717718718","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.401"},{"key":"bibr5-1753944717718718","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f5307"},{"key":"bibr6-1753944717718718","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.06.1170"},{"key":"bibr7-1753944717718718","doi-asserted-by":"publisher","DOI":"10.1007\/s40291-013-0022-y"},{"key":"bibr8-1753944717718718","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2013.03.022"},{"key":"bibr9-1753944717718718","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2006.02237.x"},{"key":"bibr10-1753944717718718","doi-asserted-by":"publisher","DOI":"10.1301\/nr.2007.dec.S234-S238"},{"key":"bibr11-1753944717718718","first-page":"396","volume":"20","author":"Derby CA","year":"2010","journal-title":"Ethn Dis"},{"key":"bibr12-1753944717718718","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.589127"},{"key":"bibr13-1753944717718718","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.976134"},{"key":"bibr14-1753944717718718","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.290"},{"key":"bibr15-1753944717718718","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002245"},{"key":"bibr16-1753944717718718","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.171488"},{"key":"bibr17-1753944717718718","doi-asserted-by":"publisher","DOI":"10.1111\/imj.12698"},{"key":"bibr18-1753944717718718","doi-asserted-by":"publisher","DOI":"10.1007\/s10903-014-0025-8"},{"key":"bibr19-1753944717718718","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0809171"},{"key":"bibr20-1753944717718718","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.04.047"},{"key":"bibr21-1753944717718718","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2017.03.010"},{"key":"bibr22-1753944717718718","doi-asserted-by":"publisher","DOI":"10.1160\/TH11-03-0202"},{"key":"bibr23-1753944717718718","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2013.04.008"},{"key":"bibr24-1753944717718718","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.jacc.2008.06.038","volume":"52","author":"Patti G","year":"2008","journal-title":"J Am Coll Cardiol"}],"container-title":["Therapeutic Advances in Cardiovascular Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753944717718718","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1753944717718718","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753944717718718","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T12:44:14Z","timestamp":1741092254000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1753944717718718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,4]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["10.1177\/1753944717718718"],"URL":"https:\/\/doi.org\/10.1177\/1753944717718718","relation":{},"ISSN":["1753-9447","1753-9455"],"issn-type":[{"type":"print","value":"1753-9447"},{"type":"electronic","value":"1753-9455"}],"subject":[],"published":{"date-parts":[[2017,7,4]]}}}