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Although experimental studies with stem cells and growth factors have shown promise, clinical trials have demonstrated inconsistent results because CLTI patients generally need arteriogenesis rather than angiogenesis. Moreover, in addition to the perfusion of the limb, there is the need to improve the neuropathic response for wound healing, especially in diabetic patients. Growth hormone (GH) is a pleiotropic hormone capable of boosting the aforementioned processes and adds special benefits for the redox balance. This hormone has the potential to mitigate symptoms in ischemic patients with no other options and improves the cardiovascular complications associated with the disease. Here, we discuss the pros and cons of using GH in such patients, focus on its effects on peripheral arteries, and analyze the possible benefits of treating CLTI with this hormone. <\/jats:p>","DOI":"10.1177\/1753944717745494","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T21:55:22Z","timestamp":1514066122000},"page":"53-72","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Chronic limb-threatening ischemia could benefit from growth hormone therapy for wound healing and limb salvage"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9599-7047","authenticated-orcid":false,"given":"Diego","family":"Caicedo","sequence":"first","affiliation":[{"name":"Department of Angiology and Vascular Surgery, Complexo Hospitalario Universitario de Pontevedra, Avda. de Mourente, s\/n; 36071-Pontevedra, Spain"},{"name":"Scientific Direction, Medical Center Foltra. Traves\u00eda Montouto, 24; 15710-Teo, A Coru\u00f1a, 15886, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Devesa","sequence":"additional","affiliation":[{"name":"Research and Development Medical Center Foltra, Teo, Spain"},{"name":"Scientific Direction, Medical Center Foltra. Traves\u00eda Montouto, 24; 15710-Teo, A Coru\u00f1a, 15886, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edctor M.","family":"Arce","sequence":"additional","affiliation":[{"name":"Department of Physiology, Santiago University School of Medicine, Spain"},{"name":"Scientific Direction, Medical Center Foltra. 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