{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:59:32Z","timestamp":1788343172090,"version":"build-2803163510"},"reference-count":44,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T00:00:00Z","timestamp":1518393600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Cardiovascular Disease"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Patency of the pedal-plantar arch limits risk of amputation in peripheral artery disease (PAD). We examined patients without chronic kidney disease (CKD)\/diabetes mellits (DM) [PAD-control], those with DM without CKD, and those with CKD without DM. <\/jats:p><\/jats:sec><jats:sec><jats:title>Method:<\/jats:title><jats:p> Uni- and multivariate logistic regression was used to assess association of CKD with loss of patency of the pedal\u2013plantar arch and presence of tibial or peroneal vessel occlusion. Multivariate models adjusted for age, sex, hypertension, hyperlipidemia and smoking. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> A total of 419 patients were included [age 75.2 \u00b1 10.3 years, 288 (69%) male]. CKD nearly doubled the unadjusted odds ratio (OR) for loss of patency of the pedal\u2013plantar arch. After adjustment, association remained significant for severe CKD [estimated glomerular filtration rate (eGFR) \u2264 29 ml\/min compared with eGFR \u2265 60 ml\/min, adjusted (adj.) OR 8.24 (95% confidence interval {CI} 0.99\u201368.36, p = 0.05)]. CKD was not related to risk of tibial or peroneal artery occlusion [PAD-control versus CKD, adj. OR 1.09 (95% CI 0.49\u20132.44, p = 0.83)] in contrast to DM [PAD\u2013control versus DM, adj. OR 2.41 (95% CI 1.23\u20134.72, p = 0.01), CKD versus DM, adj. OR 2.21 (95% CI 0.93\u20135.22); p = 0.07)]. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p> Below the knee (BTK) vascular pattern differs in patients with either DM or CKD alone. Severe CKD is a risk factor for loss of patency of the pedal\u2013plantar arch. <\/jats:p><\/jats:sec>","DOI":"10.1177\/1753944718756605","type":"journal-article","created":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T15:08:40Z","timestamp":1518448120000},"page":"145-153","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":18,"title":["Patency of the arterial pedal\u2013plantar arch in patients with chronic kidney disease or diabetes mellitus"],"prefix":"10.1177","volume":"12","author":[{"given":"Axel","family":"Haine","sequence":"first","affiliation":[{"name":"Swiss Cardiovascular Center, Division of Angiology, Bern University Hospital, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan G.","family":"Haynes","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, University of Bern, Switzerland Institute of Social and Preventive Medicine (ISPM), University 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