{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T23:31:52Z","timestamp":1787959912359,"version":"build-2784847793"},"reference-count":31,"publisher":"SAGE Publications","issue":"12","license":[{"start":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T00:00:00Z","timestamp":1542240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Cardiovascular Disease"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> There have been significant advances in the treatment of patients with cardiomyopathy with reduced ejection fraction (EF &lt; 40%). However, there is a dearth of information in the treatment of patients with cardiomyopathy and midrange EF (40\u201350%). Current guidelines state to treat these patients similarly to patients with cardiomyopathy and preserved EF. Data from the Prevention of Events with Angiotensin-Converting Enzyme Inhibition (PEACE) trial were used to elucidate whether angiotensin-converting enzyme (ACE) inhibitors improve clinical outcomes in patients with ischemic cardiomyopathy and midrange EF. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> A post hoc subgroup analysis of the PEACE trial was conducted to evaluate the effect of ACE inhibitors in a subgroup of patients with ischemic cardiomyopathy and midrange EF (40\u201350%). A Chi-square test and a Student\u2018s t-test were used to examine and compare the binary and continuous variables of baseline characteristics and outcomes between experimental and comparison groups. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> We studied a subgroup of patients from the PEACE trial with ischemic cardiomyopathy and midrange EF ( n = 2512 of 8290 total patients). Patients were assigned to either the interventional group ( n = 1247) or the placebo group ( n = 1265). There were no significant differences in baseline demographic and health characteristics between the two groups. During a total of 7 years (mean 4.7 years) of follow up, the risk of composite outcomes [all-cause mortality, nonfatal myocardial infarction, and stroke; relative risk (RR) 0.79, 95% confidence interval (CI) 0.63\u20130.98; p = 0.03] and all-cause mortality (RR 0.85, 95% CI 0.73\u20130.99; p = 0.03) was reduced in patients treated with trandolapril. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> This study revealed the benefit of ACE inhibitors among patients with ischemic cardiomyopathy and midrange EF. <\/jats:p><\/jats:sec>","DOI":"10.1177\/1753944718809266","type":"journal-article","created":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T05:18:27Z","timestamp":1542345507000},"page":"351-359","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["The effect of angiotensin-converting enzyme inhibitors on clinical outcomes in patients with ischemic cardiomyopathy and midrange ejection fraction: a <i>post hoc<\/i> subgroup analysis from the PEACE trial"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1852-4059","authenticated-orcid":false,"given":"Talal","family":"Alzahrani","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, George Washington University, 2150 Pennsylvania Ave NW, Fourth Floor, Washington, DC, 20037, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Tiu","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, George Washington University, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurusher","family":"Panjrath","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, George Washington University, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen","family":"Solomon","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, George Washington University, Washington, DC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,11,15]]},"reference":[{"key":"bibr1-1753944718809266","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000485"},{"key":"bibr2-1753944718809266","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw128"},{"key":"bibr3-1753944718809266","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp1410241"},{"key":"bibr4-1753944718809266","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.04.025"},{"key":"bibr5-1753944718809266","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14285-7"},{"key":"bibr6-1753944718809266","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0805450"},{"key":"bibr7-1753944718809266","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.628347"},{"key":"bibr8-1753944718809266","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1313731"},{"key":"bibr9-1753944718809266","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv464"},{"key":"bibr10-1753944718809266","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.159"},{"key":"bibr11-1753944718809266","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1091."},{"key":"bibr12-1753944718809266","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.03.032"},{"key":"bibr13-1753944718809266","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042739"},{"key":"bibr14-1753944718809266","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.945"},{"key":"bibr15-1753944718809266","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.813"},{"key":"bibr16-1753944718809266","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200001203420301"},{"key":"bibr17-1753944718809266","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14286-9"},{"key":"bibr18-1753944718809266","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2006.10.021"},{"key":"bibr19-1753944718809266","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-007-6068-5"},{"key":"bibr20-1753944718809266","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)05012-0"},{"key":"bibr21-1753944718809266","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.23.2981"},{"key":"bibr22-1753944718809266","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08089-3"},{"key":"bibr23-1753944718809266","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200305000-00011"},{"key":"bibr24-1753944718809266","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000236119.96301.f2"},{"key":"bibr25-1753944718809266","doi-asserted-by":"publisher","DOI":"10.1016\/S1262-3636(07)70147-7"},{"key":"bibr26-1753944718809266","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-9877(02)00234-7"},{"key":"bibr27-1753944718809266","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2004.07.001"},{"key":"bibr28-1753944718809266","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108013250501"},{"key":"bibr29-1753944718809266","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0140-6736(99)12323-7","volume":"355","author":"Effects of ramipril on cardiovascular and microvascular outcomes in people with diabetes mellitus: results of the HOPE study and MICRO-HOPE substudy","year":"2000","journal-title":"Lancet"},{"key":"bibr30-1753944718809266","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.07.013"},{"key":"bibr31-1753944718809266","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2017.06.013"}],"container-title":["Therapeutic Advances in Cardiovascular Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753944718809266","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1753944718809266","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1753944718809266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T11:52:51Z","timestamp":1740829971000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1753944718809266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,15]]},"references-count":31,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1177\/1753944718809266"],"URL":"https:\/\/doi.org\/10.1177\/1753944718809266","relation":{},"ISSN":["1753-9447","1753-9455"],"issn-type":[{"value":"1753-9447","type":"print"},{"value":"1753-9455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,15]]}}}