{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T14:55:35Z","timestamp":1753887335649,"version":"3.41.2"},"reference-count":20,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"national institutes of health","doi-asserted-by":"publisher","award":["ICA-CDRF-2016-02-068"],"award-info":[{"award-number":["ICA-CDRF-2016-02-068"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Cardiovascular Disease"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec><jats:title>Introduction:<\/jats:title><jats:p> Hypertrophic cardiomyopathy (HCM) patients with left ventricular (LV) mid-cavity obstruction (LVMCO) often experience severe drug-refractory symptoms thought to be related to intraventricular obstruction. We tested whether ventricular pacing, guided by invasive haemodynamic assessment, reduced LVMCO and improved refractory symptoms. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Between December 2008 and December 2017, 16 HCM patients with severe refractory symptoms and LVMCO underwent device implantation with haemodynamic pacing study to assess the effect on invasively defined LVMCO gradients. The effect on the gradient of atrioventricular (AV) synchronous pacing from sites including right ventricular (RV) apex and middle cardiac vein (MCV) was retrospectively assessed. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Invasive haemodynamic data were available in 14 of 16 patients. Mean pre-treatment intracavitary gradient was 77\u2009\u00b1\u200922\u2009mmHg (in sinus rhythm) versus 21\u2009\u00b1\u200921\u2009mmHg during pacing from optimal ventricular site (95% CI: \u221270.86 to \u221240.57, p\u2009&lt;\u20090.0001). Optimal pacing site was distal MCV in 12\/16 (86%), RV apex in 1\/16 and via epicardial LV lead in 1\/16. Pre-pacing Doppler-derived gradients were significantly higher than at follow-up (47\u2009\u00b1\u200915 versus 24\u2009\u00b1\u200916\u2009mmHg, 95% CI: \u221237.19 to \u221213.73, p\u2009&lt;\u20090.001). Median baseline NYHA class was 3, which had improved by \u2a7e1 NYHA class in 13 of 16 patients at 1-year post-procedure ( p\u2009&lt;\u20090.001). The mean follow-up duration was 4.6\u2009\u00b1\u20092.7\u2009years with the following outcomes: 8\/16 (50%) had continued symptomatic improvement, 4\/16 had symptomatic decline and 4\/16 died. Contributors to symptomatic decline included chronic atrial fibrillation (AF) ( n\u2009=\u20095), phrenic nerve stimulation ( n\u2009=\u20093) and ventricular ectopy ( n\u2009=\u20091). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> In drug-refractory symptomatic LVMCO, distal ventricular pacing can reduce intracavitary obstruction and may provide long-term symptomatic relief in patients with limited treatment options. A haemodynamic pacing study is an effective strategy for identifying optimal pacing site and configuration. <\/jats:p><\/jats:sec>","DOI":"10.1177\/17539447221108816","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T12:30:39Z","timestamp":1659443439000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Therapeutic benefits of distal ventricular pacing in mid-cavity obstructive hypertrophic cardiomyopathy"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9860-3800","authenticated-orcid":false,"given":"James W.","family":"Malcolmson","sequence":"first","affiliation":[{"name":"Barts Heart Centre, St Bartholomew\u2019s Hospital, London, UK"},{"name":"The William Harvey Heart Centre, William Harvey Research Institute, Queen Mary University of London, London, UK"},{"name":"NIHR Biomedical Research Centre at Barts, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca K.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Barts Heart Centre, St Bartholomew\u2019s Hospital, London, UK"},{"name":"Institute of Cardiovascular Science, University College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhishek","family":"Joshi","sequence":"additional","affiliation":[{"name":"Barts Heart Centre, St Bartholomew\u2019s Hospital, London, UK"},{"name":"NIHR Biomedical Research Centre at Barts, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jackie","family":"Cooper","sequence":"additional","affiliation":[{"name":"NIHR Biomedical Research Centre at Barts, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Breitenstein","sequence":"additional","affiliation":[{"name":"University Heart Centre, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Ginks","sequence":"additional","affiliation":[{"name":"Oxford University Hospitals, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen E.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Barts Heart Centre, St Bartholomew\u2019s Hospital, London, UK"},{"name":"The William Harvey Heart Centre, William Harvey Research Institute, Queen Mary University of London, London, UK"},{"name":"NIHR Biomedical Research Centre at Barts, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saidi A.","family":"Mohiddin","sequence":"additional","affiliation":[{"name":"Barts Heart Centre, St Bartholomew\u2019s Hospital, London, UK"},{"name":"The William Harvey Heart Centre, William Harvey Research Institute, Queen Mary University of London, London, UK"},{"name":"NIHR Biomedical Research Centre at Barts, London, 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