{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T08:13:44Z","timestamp":1776068024530,"version":"3.50.1"},"reference-count":29,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007867","name":"universit\u00e9 laval","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007867","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Cardiovascular Disease"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec><jats:title>Objective:<\/jats:title><jats:p> Pharmacological management of heart failure and comorbidities may result in polypharmacy, but there are few population-based studies that portray the use of medications over time. We aimed to describe the trends in polypharmacy and medication use in older adults with heart failure. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> We performed a study including all adults &gt;65\u2009years with heart failure between 2000 and 2017 using health administrative databases in Quebec, Canada. Medication use was ascertained by the presence of at least one claim in each year. We defined three levels of polypharmacy: \u2a7e10, \u2a7e15 and \u2a7e20 different medications\/year, and evaluated the use of guideline-recommended and potentially inappropriate medications. We calculated age- and sex-standardized proportions of users each year. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> The use of \u2a7e10, \u2a7e15 and \u2a7e20 medications increased from 62.2%, 30.6% and 12.2% in 2000 to 71.9%, 43.9% and 22.7%, respectively, in 2017. The combination of \u03b2-blocker and angiotensin-converting enzyme inhibitor (ACEI)\/angiotensin II receptor blocker (ARB) was used by 30.4% of individuals in 2000 and 45.5% in 2017. ACEI\/ARB users decreased from 65.8% in 2000 to 62.1% in 2017. Potentially inappropriate medication use decreased over time. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> Polypharmacy is significant among older adults with heart failure. Implications of such medication burden should be investigated. <\/jats:p><\/jats:sec>","DOI":"10.1177\/17539447221113946","type":"journal-article","created":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T12:19:01Z","timestamp":1658578741000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Polypharmacy among older individuals with heart failure: trends between 2000 and 2017 in the province of Quebec, Canada"],"prefix":"10.1177","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3734-2165","authenticated-orcid":false,"given":"Alexandre","family":"Campeau Calfat","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Simard","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec, QC, Canada"},{"name":"Institut national de sant\u00e9 publique du Qu\u00e9bec, Qu\u00e9bec, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amina","family":"Ouali","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universit\u00e9 Laval, Qu\u00e9bec, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5299-9691","authenticated-orcid":false,"given":"Claudia","family":"Blais","sequence":"additional","affiliation":[{"name":"Institut national de sant\u00e9 publique du Qu\u00e9bec, Qu\u00e9bec, QC, Canada"},{"name":"Faculty of Pharmacy, Universit\u00e9 Laval, Qu\u00e9bec, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Sirois","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Universit\u00e9 Laval, CEVQ, 1050 Chemin Ste-Foy, Qu\u00e9bec, QC G1S 4L8, Canada"},{"name":"Institut national de sant\u00e9 publique du Qu\u00e9bec, Qu\u00e9bec, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,7,23]]},"reference":[{"key":"bibr1-17539447221113946","doi-asserted-by":"publisher","DOI":"10.24095\/hpcdp.35.10.02"},{"key":"bibr2-17539447221113946","volume-title":"Surveillance de l\u2019insuffisance cardiaque au Qu\u00e9bec: pr\u00e9valence, incidence et mortalit\u00e9 de 2005-2006 \u00e0 2015-2016","author":"Massamba VK","year":"2019"},{"key":"bibr3-17539447221113946","doi-asserted-by":"publisher","DOI":"10.1007\/s11897-014-0186-8"},{"key":"bibr4-17539447221113946","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.1594"},{"key":"bibr5-17539447221113946","first-page":"464","volume":"42","author":"Shah A","year":"2017","journal-title":"P T"},{"key":"bibr6-17539447221113946","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2017.08.022"},{"key":"bibr7-17539447221113946","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2014.10.022"},{"key":"bibr8-17539447221113946","doi-asserted-by":"publisher","DOI":"10.1016\/S0828-282X(06)70237-9"},{"key":"bibr9-17539447221113946","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2010.08.017"},{"key":"bibr10-17539447221113946","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.132"},{"key":"bibr11-17539447221113946","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000426"},{"key":"bibr12-17539447221113946","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15654"},{"key":"bibr13-17539447221113946","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2012.02.018"},{"key":"bibr14-17539447221113946","doi-asserted-by":"publisher","DOI":"10.24095\/hpcdp.34.4.06"},{"key":"bibr15-17539447221113946","doi-asserted-by":"publisher","DOI":"10.24095\/hpcdp.33.3.06"},{"key":"bibr16-17539447221113946","first-page":"85","volume":"20","author":"Pampalon R","year":"2009","journal-title":"Health Rep"},{"key":"bibr17-17539447221113946","volume-title":"Portrait de la polypharmacie chez les a\u00een\u00e9s qu\u00e9b\u00e9cois entre 2000 et 2016","author":"Gosselin E","year":"2020"},{"key":"bibr18-17539447221113946","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00326"},{"key":"bibr19-17539447221113946","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.13766"},{"key":"bibr20-17539447221113946","doi-asserted-by":"publisher","DOI":"10.1080\/15412555.2019.1646716"},{"key":"bibr21-17539447221113946","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCHEARTFAILURE.120.006977"},{"key":"bibr22-17539447221113946","doi-asserted-by":"publisher","DOI":"10.1016\/j.hfc.2013.12.001"},{"key":"bibr23-17539447221113946","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e6341"},{"key":"bibr24-17539447221113946","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12842"},{"key":"bibr25-17539447221113946","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13392"},{"key":"bibr26-17539447221113946","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010713"},{"key":"bibr27-17539447221113946","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14284-5"},{"key":"bibr28-17539447221113946","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2018.03.006"},{"key":"bibr29-17539447221113946","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006239"}],"container-title":["Therapeutic Advances in Cardiovascular Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17539447221113946","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/17539447221113946","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/17539447221113946","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T17:31:53Z","timestamp":1741023113000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/17539447221113946"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":29,"alternative-id":["10.1177\/17539447221113946"],"URL":"https:\/\/doi.org\/10.1177\/17539447221113946","relation":{},"ISSN":["1753-9447","1753-9455"],"issn-type":[{"value":"1753-9447","type":"print"},{"value":"1753-9455","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"article-number":"17539447221113946"}}