{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T14:30:31Z","timestamp":1793457031029,"version":"4.5.0"},"reference-count":50,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Cardiovascular Disease"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Determinants of coronary artery disease, such as endothelial dysfunction and oxidative stress, could be attenuated by high-intensity aerobic interval exercise training (HIIT). However, the volume of this type of training is not well established. <\/jats:p><\/jats:sec><jats:sec><jats:title>Objective:<\/jats:title><jats:p> To assess the impact of two volumes of HIIT, low (LV-HIIT, &lt;10\u2009min at high intensity) and high (HV-HIIT, &gt;10\u2009min at high intensity), on vascular-endothelial function in individuals after an acute myocardial infarction (AMI). <\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods:<\/jats:title><jats:p> Clinical trial in 80\u2009AMI patients (58.4\u2009\u00b1\u20098.3\u2009years, 82.5% men) with three study groups: LV-HIIT ( n\u2009=\u200928) and HV-HIIT ( n\u2009=\u200928) with two sessions per week for 16\u2009weeks and control group (CG, n\u2009=\u200924) with unsupervised physical activity recommendations. Endothelial function (brachial flow-mediated dilation, FMD), atherosclerosis (carotid intima-media thickness ultrasound, cIMT), and levels of oxidized low-density lipoprotein (ox-LDL) as a marker of oxidative stress were determined before and after the intervention period. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> After the intervention, in the exercise groups, there was an increase in FMD (LV-HIIT, \u219158.8%; HV-HIIT, \u219194.1%; p\u2009&lt;\u20090.001) concurrently with a decrease in cIMT (LV-HIIT, \u21933.0%; HV-HIIT, \u21933.2%; p\u2009=\u20090.019) and LDLox (LV-HIIT, \u21935.2%; HV-HIIT, \u21938.9%; p\u2009&lt;\u20090.001), with no significant changes in the CG. Furthermore, a significant inverse correlation was observed between ox-LDL and endothelial function related to the volume of HIIT training performed (LV-HIIT: r\u2009=\u2009\u22120.376, p\u2009=\u20090.031; HV-HIIT: r\u2009=\u2009\u22120.490, p\u2009&lt;\u20090.004), with no significance in the CG ( r\u2009=\u20090.021, p\u2009=\u20090.924). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> In post-AMI patients, HIIT may lead to a volume-dependent enhancement in endothelial function, attributed to a decrease in oxidative stress, with added beneficial effects in reducing vascular wall thickness. An LV-HIIT program, with less than 10\u2009min at high intensity per session, has proven enough efficiency to initiate favorable vascular-endothelial adaptations, potentially reducing cardiovascular risk among patients with coronary artery disease. <\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration:<\/jats:title><jats:p> INTERFARCT, ClinicalTrials.gov: NCT02876952. <\/jats:p><\/jats:sec>","DOI":"10.1177\/17539447241286036","type":"journal-article","created":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T01:14:31Z","timestamp":1728522871000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Vascular-endothelial adaptations following low and high volumes of high-intensity interval training in patients after myocardial infarction"],"prefix":"10.1177","volume":"18","author":[{"given":"Rodrigo","family":"Aispuru-Lanche","sequence":"first","affiliation":[{"name":"Department of Physical 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