{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:46:20Z","timestamp":1791359180040,"version":"4.3.1"},"reference-count":32,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"NOVARTIS Singapore"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Cardiovascular Disease"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Elevated lipoprotein(a) [Lp(a)] is a common hyperlipidaemic condition with strong genetic predisposition and is independently associated with ischaemic heart disease (IHD). A Mendelian randomisation study has suggested that elevated Lp(a) is likely to confer similar causal risks as heterozygous familial hypercholesterolemia for premature IHD. We aimed to characterise the clinical profiles of admitted patients with IHD with at least one Lp(a) measurement. We also investigated whether elevated Lp(a) concentration was associated with premature onset of IHD. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> This is a descriptive, non-interventional, retrospective study with data from a single tertiary hospital IHD Lp(a) cohort in Singapore, which consecutively recruited 521 patients with IHD admitted to the hospital. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> A total of 82.2% were men, 46.6% had newly diagnosed IHD and 10% had premature IHD. The median Lp(a) levels was 35.2\u2009nmol\/L. 70.8% of patients had normal Lp(a) concentrations (&lt;70\u2009nmol\/L), 13.4% of people with Lp(a)\u2009\u2a7e\u200970 to &lt;120\u2009nmol\/L and 15.7% of patients with Lp(a)\u2009\u2a7e\u2009120\u2009nmol\/L. Lp(a) distribution was positively skewed to the right for all ethnicities. Patients of Indian ethnicity and of female gender had higher levels of Lp(a) compared with other ethnicities and gender, respectively. Multivariable regression analysis identified Lp(a)\u2009\u2a7e\u2009155\u2009mmol\/L to be associated with development of premature IHD (OR\u2009=\u20092.90, 95% CI: 1.26\u20136.67, p\u2009=\u20090.012). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> There exist differences in Lp(a) distribution across ethnicities and gender. The subgroup analysis suggests that Lp(a)\u2009\u2a7e\u2009155\u2009mmol\/L was associated with premature onset of IHD. <\/jats:p><\/jats:sec>","DOI":"10.1177\/17539447241306936","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T06:31:54Z","timestamp":1733985114000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Lipoprotein(a) distribution in hospitalised Asian patients with ischaemic heart disease"],"prefix":"10.1177","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5593-907X","authenticated-orcid":false,"given":"Wann Jia","family":"Loh","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Changi General Hospital, 2 Simei Street 3, Singapore 529889, Singapore"},{"name":"Duke-NUS Medical School, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong Boon","family":"Teo","sequence":"additional","affiliation":[{"name":"Yong Loo Lin School of Medicine, National University Singapore, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Simon","sequence":"additional","affiliation":[{"name":"Novartis (Singapore) Pte Ltd, Singapore, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Yeo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Changi General Hospital, Singapore, 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