{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T18:39:44Z","timestamp":1769366384421,"version":"3.49.0"},"reference-count":43,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100016834","name":"chongqing municipal health commission","doi-asserted-by":"publisher","award":["2022MSXM177"],"award-info":[{"award-number":["2022MSXM177"]}],"id":[{"id":"10.13039\/100016834","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Yongchuan District Science and Technology Bureau","award":["2021yc-cxfz30017"],"award-info":[{"award-number":["2021yc-cxfz30017"]}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therapeutic Advances in Cardiovascular Disease"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Inflammation significantly impacts disease progression and prognosis in acute pulmonary embolism (APE); however, the optimal method to quantify this inflammation for prognostic purposes remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>We aimed to identify the most effective blood-based inflammatory marker for predicting short-term mortality in patients with APE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>We retrospectively analyzed 301 patients with APE. We compared the predictive performance of nine inflammatory markers for 30-day mortality, focusing on the inflammatory burden index (IBI), and contrasted it with the standard clinical score (sPESI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>After adjusting for potential confounders, a higher IBI was strongly and independently associated with an increased risk of 30-day mortality. IBI demonstrated superior predictive ability compared with all other inflammatory markers and the sPESI score. The relationship between IBI and mortality risk was linear; higher IBI values corresponded to greater mortality risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>IBI is a robust and independent predictor of short-term survival in patients with APE. Calculated from routine blood tests (C-reactive protein, neutrophil, and lymphocyte counts), it offers a simple, rapid, and cost-effective tool that may enhance early risk stratification and guide personalized treatment decisions in clinical practice. Further validation in independent cohorts is required to confirm its prognostic utility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1177\/17539447251407467","type":"journal-article","created":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T10:03:02Z","timestamp":1767434582000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["A novel predictor of short-term prognosis in acute pulmonary embolism: inflammatory burden index"],"prefix":"10.1177","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6278-0565","authenticated-orcid":false,"given":"Lingwei","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Geriatrics, The Affiliated Yongchuan Hospital of Chongqing Medical University, Yongchuan, Chongqing, China"},{"name":"Chongqing Municipality Clinical Research Center for Geriatric Diseases (Yongchuan Hospital, Chongqing Medical University), Yongchuan, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Sichuan University Hospital, Sichuan University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meimei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, West China Hospital of Sichuan University, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zixing","family":"Wu","sequence":"additional","affiliation":[{"name":"Chongqing Municipality Clinical Research Center for Geriatric Diseases (Yongchuan Hospital, Chongqing Medical University), Yongchuan, Chongqing, China"},{"name":"Department of General Practice, The Affiliated Yongchuan Hospital of Chongqing Medical University, Yongchuan, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9209-7747","authenticated-orcid":false,"given":"Fei","family":"He","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, The Affiliated Yongchuan Hospital of Chongqing Medical University, Yongchuan, Chongqing 402160, China"},{"name":"Chongqing Municipality Clinical Research Center for Geriatric Diseases (Yongchuan Hospital, Chongqing Medical University), Chongqing 402160, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2026,1,3]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11040615"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0044-1779011"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-1772840"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11739-015-1388-0"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2025.133422"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/10760296211064898"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.5152\/TurkThoracJ.2020.19048"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0044-1785487"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25094941"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e21068"},{"issue":"4","key":"e_1_3_4_12_2","first-page":"4438","article-title":"Battle of the biomarkers of systemic inflammation","volume":"14","author":"Stec-Martyna E","year":"2025","unstructured":"Stec-Martyna E, Wojtczak K, Nowak D, et al. 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