{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T05:20:35Z","timestamp":1771651235669,"version":"3.50.1"},"reference-count":60,"publisher":"Informa UK Limited","issue":"3","license":[{"start":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T00:00:00Z","timestamp":1376265600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Menopause International"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p>Cardiovascular disease remains a leading cause of morbidity and mortality in menopausal women in spite of the overall reduction in age-adjusted mortality from the disease in the last few years. It is now clear that mechanisms of cardiovascular disease in menopausal women are similar to men and rather than midlife acceleration of cardiovascular disease in women, the final impact of cardiovascular disease in later life may be a reflection of cardiovascular changes during reproductive years as a result of woman\u2019s obstetric history. A decade after the Women\u2019s Health Initiative trial, there is upcoming evidence to suggest that hormone replacement therapy in young recently menopausal women has a cardioprotective effect. Cardiovascular changes during normal pregnancy or pregnancy complications such as preeclampsia may affect a woman\u2019s long-term cardiovascular health. Therefore, it is plausible that the cardioprotective benefit of hormone replacement therapy depends on occult pre-existing cardiovascular risks in women in relation to their previous obstetric history. In this review, we describe the cardiovascular changes during and after pregnancy in obstetric complications such as recurrent miscarriage, preeclampsia, intrauterine growth restriction, preterm labour and gestational diabetes; existing evidence regarding their association with cardiovascular disease later in life, and hypothesize possible mechanisms. Our aim is to improve the understanding and highlight the importance of including obstetric history in risk assessment in menopausal women and individualizing their risks before prescribing hormone replacement therapy. Future research in risk benefit assessment of hormone replacement therapy should also account for a woman\u2019s background cardiovascular risk in the light of her obstetric history.<\/jats:p>","DOI":"10.1177\/1754045313495675","type":"journal-article","created":{"date-parts":[[2013,8,12]],"date-time":"2013-08-12T20:45:55Z","timestamp":1376340355000},"page":"115-120","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":14,"title":["Cardiovascular disease in menopause: Does the obstetric history have any bearing?"],"prefix":"10.1080","volume":"19","author":[{"given":"Amita A","family":"Mahendru","sequence":"first","affiliation":[{"name":"Queen\u2019s Medical Centre, Nottingham University Hospitals NHS Trust, Nottingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Morris","sequence":"additional","affiliation":[{"name":"Norfolk and Norwich University Hospital, Norwich, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2013,8,12]]},"reference":[{"key":"bibr1-1754045313495675","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31820faaf8"},{"key":"bibr2-1754045313495675","unstructured":"Scarborough P, Bhatnagar P, Wickramasinghe K, et\u00a0al. 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