{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:43:27Z","timestamp":1791089007720,"version":"4.1.0"},"reference-count":53,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2014,3,5]],"date-time":"2014-03-05T00:00:00Z","timestamp":1393977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:p>\n                    Otilonium bromide (OB) is a spasmolytic compound of the family of quaternary ammonium derivatives and has been successfully used in the treatment of patients with irritable bowel syndrome (IBS) due to its specific pharmacodynamic effects on motility patterns in the human colon and the contractility of colonic smooth muscle cells. This article examines how. OB inhibits the main patterns of human sigmoid motility\n                    <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                    , which are spontaneous rhythmic phasic contractions, smooth muscle tone, contractions induced by stimulation of excitatory motor neurons and contractions induced by direct effect of excitatory neurotransmitters. It does this mainly by blocking calcium influx through L-type calcium channels and interfering with mobilization of cellular calcium required for smooth muscle contraction, thereby limiting excessive intestinal contractility and abdominal cramping. OB also inhibits T-type calcium channels and muscarinic responses. Finally, OB inhibits tachykinin receptors on smooth muscle and primary afferent neurons which may have the joint effect of reducing motility and abdominal pain. All these mechanisms mediate the therapeutic effects of OB in patients with IBS and might be useful in patients with other spastic colonic motility disorders such as diverticular disease.\n                  <\/jats:p>","DOI":"10.1177\/1756283x14525250","type":"journal-article","created":{"date-parts":[[2014,3,5]],"date-time":"2014-03-05T20:55:37Z","timestamp":1394052937000},"page":"156-166","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Colonic smooth muscle cells and colonic motility patterns as a target for irritable bowel syndrome therapy: mechanisms of action of otilonium bromide"],"prefix":"10.1177","volume":"7","author":[{"given":"Jakub","family":"Rychter","sequence":"first","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Esp\u00edn","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Barcelona, Spain"},{"name":"Department of Surgery, Hospital de Matar\u00f3, Matar\u00f3, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Gallego","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patri","family":"Vergara","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Barcelona, Spain"},{"name":"Department of Cell Biology, Physiology and Immunology, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd), Instituto de Salud Carlos III, Barcelona, Spain"},{"name":"Department of Cell Biology, Physiology and Immunology, Universitat Aut\u00f2noma de Barcelona, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pere","family":"Clav\u00e9","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hospital de Matar\u00f3, Universitat Aut\u00f3noma de Barcelona, C\/ Cirera s\/n, Matar\u00f3, Barcelona 08304, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,3,5]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.332"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-013-0328-2"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1998.00397.x"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X11415892"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-012-1598-0"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2011.17.4.402"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03804.x"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2010.01594.x"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2011.04730.x"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(96)00275-8"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-4257(01)00020-1"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12170"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.37095"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612043382972"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-9556(24)15142-2"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.1998.0340"},{"key":"e_1_3_2_18_1","first-page":"25","article-title":"The use of anti-spasmodics in the treatment of irritable bowel syndrome: focus on otilonium bromide","volume":"16","author":"Forte E.","year":"2012","unstructured":"Forte E., Pizzoferrato M., Lopetuso L., Scaldaferri F. 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