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We describe a case of a 16-year-old female with homozygous sickle cell anemia who presented to the emergency room with fatigue, malaise, dark urine, lower back pain, scleral icterus and jaundice. She was found to have marked hyperbilirubinemia, which persisted after exchange transfusion. Because of the concomitant presence of gallstones and choledocholithiasis, the patient underwent endoscopic ultrasound and laparoscopic cholecystectomy followed by endoscopic retrograde cholangiography and sphincterotomy.<\/jats:p>","DOI":"10.1177\/1756283x14530781","type":"journal-article","created":{"date-parts":[[2014,5,13]],"date-time":"2014-05-13T22:22:52Z","timestamp":1400019772000},"page":"217-223","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Acute liver function decompensation in a patient with sickle cell disease managed with exchange transfusion and endoscopic retrograde cholangiography"],"prefix":"10.1177","volume":"7","author":[{"given":"Haris","family":"Papafragkakis","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, The Brooklyn Hospital Center, 121 DeKalb Ave, Brooklyn, NY 11201, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mel A.","family":"Ona","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Brooklyn Hospital Center, Brooklyn, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kinesh","family":"Changela","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Brooklyn Hospital Center, Brooklyn, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swayamprabha","family":"Sadanandan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\/Oncology, The Brooklyn Hospital Center, Brooklyn, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham","family":"Jelin","sequence":"additional","affiliation":[{"name":"Department of Pediatric Gastroenterology, The Brooklyn Hospital Center, Brooklyn, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sury","family":"Anand","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Brooklyn Hospital Center, Brooklyn, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushil","family":"Duddempudi","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The Brooklyn Hospital Center, Brooklyn, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,5,12]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.20317"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLE.0b013e3182471b1c"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000184446.52454.69"},{"key":"e_1_3_2_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0377-4929.41698"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2001.24114"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(80)80008-8"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.4081\/hr.2013.e1"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.295.6592.234"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1975.03250070034021"},{"key":"e_1_3_2_11_1","first-page":"1183","article-title":"Case of fatal sickle cell intrahepatic cholestasis despite use of exchange transfusion in an African-American patient","volume":"98","author":"Costa D.","year":"2006","unstructured":"Costa D., Miksad R., Buff M., Wang Y., Dezube B. 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