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Its antiangiogenic effect is greater than that of its related drug, sorafenib. Regorafenib has been approved by the US Food and Drug Administration (FDA) for the treatment of metastatic colorectal cancer (mCRC) in patients who have failed treatment with fluoropyrimidine, oxaliplatin and irinotecan based chemotherapy, an anti-VEGF therapy and, if KRAS wild type, an anti-EGFR therapy. The FDA based this approval on data from the CORRECT trial, which showed the efficacy of regorafenib compared with placebo. The most common grade 3\u20134 adverse reactions with the drug are hand foot skin reactions (HFSR), diarrhea, hypertension and fatigue. This review discusses the efficacy data, and the incidence and management of regorafenib\u2019s toxicities. <\/jats:p>","DOI":"10.1177\/1756283x15580743","type":"journal-article","created":{"date-parts":[[2015,5,8]],"date-time":"2015-05-08T01:42:18Z","timestamp":1431049338000},"page":"285-297","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":94,"title":["Management of regorafenib-related toxicities: a review"],"prefix":"10.1177","volume":"8","author":[{"given":"Saravanan K.","family":"Krishnamoorthy","sequence":"first","affiliation":[{"name":"Columbia University Medical Center, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Relias","sequence":"additional","affiliation":[{"name":"Division of Hematology\/Oncology and Experimental Therapeutics, Tufts Medical Center, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunit","family":"Sebastian","sequence":"additional","affiliation":[{"name":"University of Mississippi, Jackson, MS, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Jayaraman","sequence":"additional","affiliation":[{"name":"University of Connecticut, Farmington, CT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Wasif","family":"Saif","sequence":"additional","affiliation":[{"name":"Department of Medicine and Cancer Center, Tufts Medical Center, 800 Washington Street Box 245, Boston, MA 02111, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,5,7]]},"reference":[{"key":"bibr1-1756283X15580743","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2014.06.003"},{"key":"bibr2-1756283X15580743","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-12-1162"},{"key":"bibr3-1756283X15580743","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602584"},{"key":"bibr4-1756283X15580743","volume-title":"Stigvara (package insert)","author":"Bayer HealthCare Pharmaceutical","year":"2012"},{"key":"bibr5-1756283X15580743","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-013-0254-4"},{"key":"bibr6-1756283X15580743","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-012-1573-x"},{"key":"bibr7-1756283X15580743","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.12-S1-43"},{"key":"bibr8-1756283X15580743","unstructured":"Common Terminology Criteria for Adverse Events (CTCAE) Version 4.0 Published 28 May 2009 (v4.03: June 14, 2010), US Department of Health and Human Services, National Institutes of Health, National Cancer Institute."},{"key":"bibr9-1756283X15580743","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076009"},{"key":"bibr10-1756283X15580743","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61857-1"},{"key":"bibr11-1756283X15580743","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2004.11.028"},{"key":"bibr12-1756283X15580743","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2010.121"},{"key":"bibr13-1756283X15580743","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1068"},{"key":"bibr14-1756283X15580743","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199512000-00002"},{"key":"bibr15-1756283X15580743","doi-asserted-by":"publisher","DOI":"10.3747\/co.20.1612"},{"key":"bibr16-1756283X15580743","volume":"32","author":"Gomes D. 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