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As vonoprazan has a long duration of action and causes rapid and strong inhibition of gastric acid secretion, it has gained clinical attention for treating erosive oesophagitis, peptic ulcers, and H. pylori infection. In this review, we discuss the recent knowledge regarding the safety and efficacy of vonoprazan, focusing on its use in H. pylori eradication. The latest literature and our clinical experience have shown that vonoprazan-based therapies have satisfactory eradication rates. Additionally, vonoprazan-based therapies are associated with similar rates of adverse events as standard triple therapies with conventional proton-pump inhibitors.<\/jats:p>","DOI":"10.1177\/1756283x16668093","type":"journal-article","created":{"date-parts":[[2016,9,23]],"date-time":"2016-09-23T01:09:16Z","timestamp":1474592956000},"page":"845-852","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":40,"title":["Vonoprazan-based therapy for<i>Helicobacter pylori<\/i>eradication: experience and clinical evidence"],"prefix":"10.1177","volume":"9","author":[{"given":"Yuko","family":"Akazawa","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Fukuda Yutaka Surgery Clinic, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Fukuda Yutaka Surgery Clinic, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,9,22]]},"reference":[{"key":"bibr1-1756283X16668093","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/S0022-3565(24)38953-0","volume":"295","author":"Abelo A.","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"bibr2-1756283X16668093","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12291"},{"key":"bibr3-1756283X16668093","doi-asserted-by":"publisher","DOI":"10.1021\/jm300318t"},{"key":"bibr4-1756283X16668093","unstructured":"Asaka M. 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