{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:27:06Z","timestamp":1790684826932,"version":"4.1.0"},"reference-count":62,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:p> Inflammatory bowel disease (IBD) is a spectrum of immune-mediated inflammatory disorders with a complex multifactorial pathogenesis, where different pathways may predominate in different individuals. This complexity will most likely require a panoply of drugs targeting different pathways if one wants to treat to steroid-free sustained remission and mucosal healing. Presently, the mainstay of medical management of IBD is based on 5-aminosalicylates, corticosteroids, thiopurines, methotrexate, antitumor necrosis factor, anti-alpha4 beta7 (\u03b14\u03b27) integrin and anti-interleukin (IL)-12\/IL-23 therapies. The discovery of new pathways involved in the pathogenesis of IBD resulted in new drugs targeting Janus kinase\/signal transducers and activators of transcription, IL-6, spingosine-1-phosphate, and phosphodiesterase 4, among others. These new therapies might result in more advantageous safety profiles. Several of these new drugs have already been successfully tested in other inflammatory disorders, such as psoriasis or rheumatoid arthritis. In this review, evidence from phase II and phase III randomized controlled clinical trials in patients with IBD involving new biologicals and small molecules are summarized. <\/jats:p>","DOI":"10.1177\/1756284819853208","type":"journal-article","created":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T05:25:05Z","timestamp":1558934705000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":112,"title":["New biologics and small molecules in inflammatory bowel disease: an update"],"prefix":"10.1177","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8892-7075","authenticated-orcid":false,"given":"Jo\u00e3o","family":"Sabino","sequence":"first","affiliation":[{"name":"Universitaire Ziekenhuizen Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3898-7093","authenticated-orcid":false,"given":"Bram","family":"Verstockt","sequence":"additional","affiliation":[{"name":"Universitaire Ziekenhuizen Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Vermeire","sequence":"additional","affiliation":[{"name":"Universitaire Ziekenhuizen Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Ferrante","sequence":"additional","affiliation":[{"name":"Universtaire Ziekenhuizen Leuven, Herestraat 49, Leuven B3000, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2019,5,26]]},"reference":[{"key":"bibr1-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2015.186"},{"key":"bibr2-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.117"},{"key":"bibr3-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.04.007"},{"key":"bibr4-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2011.10.001"},{"key":"bibr5-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjw168"},{"key":"bibr6-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjx009"},{"key":"bibr7-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2017.05.015"},{"key":"bibr8-1756284819853208","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1401867"},{"key":"bibr9-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606910"},{"key":"bibr10-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312735"},{"key":"bibr11-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.01.029"},{"key":"bibr12-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32537-5"},{"key":"bibr13-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(17)34357-3"},{"key":"bibr14-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjx180.400"},{"key":"bibr15-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjy085"},{"key":"bibr16-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210457"},{"key":"bibr17-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key339"},{"key":"bibr18-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.08.040190.001345"},{"key":"bibr19-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209668"},{"key":"bibr20-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1038\/nature22352"},{"key":"bibr21-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2017.02.002"},{"key":"bibr22-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1513248"},{"key":"bibr23-1756284819853208","volume-title":"Paper presented at United European Gastroenterology Week 2018, Vienna, Austria","author":"Sandborn WJ"},{"key":"bibr24-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000154520.48391.69"},{"key":"bibr25-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.02.019"},{"key":"bibr26-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-307118"},{"key":"bibr27-1756284819853208","unstructured":"Active Biotech regains global rights to development and commercialization of laquinimod, https:\/\/www.activebiotech.com\/en\/media\/pressreleases\/?id=2214295&date=1536132600 (2018, accessed 25 November 2018)."},{"key":"bibr28-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-014-7264-4"},{"key":"bibr29-1756284819853208","unstructured":"Teva and Active Biotech announce CONCERTO trial of laquinimod in RRMS did not meet primary endpoint. https:\/\/tevapharm.com\/news\/teva_and_active_biotech_announce_concerto_trial_of_laquinimod_in_rrms_did_not_meet_primary_endpoint_05_17.aspx (2017, accessed 25 November 2018)."},{"key":"bibr30-1756284819853208","first-page":"97","volume":"151","author":"Briskin M","year":"1997","journal-title":"Am J Pathol"},{"key":"bibr31-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020732"},{"key":"bibr32-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215739"},{"key":"bibr33-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215734"},{"key":"bibr34-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051586"},{"key":"bibr35-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051782"},{"key":"bibr36-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa051847"},{"key":"bibr37-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.08.044"},{"key":"bibr38-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2567.1996.d01-727.x"},{"key":"bibr39-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60661-9"},{"key":"bibr40-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.10.041"},{"key":"bibr41-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-313457"},{"key":"bibr42-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30930-3"},{"key":"bibr43-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjx002.034"},{"key":"bibr44-1756284819853208","doi-asserted-by":"crossref","DOI":"10.1093\/ecco-jcc\/jjx005","volume":"11","author":"Sandborn WJ","year":"2017","journal-title":"J Crohns Colitis"},{"key":"bibr45-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3895"},{"key":"bibr46-1756284819853208","volume":"16","author":"Moschen AR","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"bibr47-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1038\/nature11582"},{"key":"bibr48-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602773"},{"key":"bibr49-1756284819853208","volume-title":"Paper presented at UEG Week 2018","author":"Sands BE"},{"key":"bibr50-1756284819853208","first-page":"1329","volume":"21","author":"Panaccione R","year":"2015","journal-title":"Inflamm Bowel Dis"},{"key":"bibr51-1756284819853208","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.7114"},{"key":"bibr52-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1607017"},{"key":"bibr53-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30570-6"},{"key":"bibr54-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30233-4"},{"key":"bibr55-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.03.049"},{"key":"bibr56-1756284819853208","volume-title":"Paper presented at Digestive Disease Week","author":"Sandborn WJ"},{"key":"bibr57-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2016.01.007"},{"key":"bibr58-1756284819853208","volume-title":"Paper presented at European Crohn\u2019s and Colitis Organisation 2018","author":"Danese S"},{"key":"bibr59-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjz046.001"},{"key":"bibr60-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15126"},{"key":"bibr61-1756284819853208","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-315494"},{"key":"bibr62-1756284819853208","author":"Verstockt B","year":"2018","journal-title":"Gut"}],"container-title":["Therapeutic Advances in Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1756284819853208","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1756284819853208","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1756284819853208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T12:17:51Z","timestamp":1740831471000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1756284819853208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":62,"alternative-id":["10.1177\/1756284819853208"],"URL":"https:\/\/doi.org\/10.1177\/1756284819853208","relation":{},"ISSN":["1756-2848","1756-2848"],"issn-type":[{"value":"1756-2848","type":"print"},{"value":"1756-2848","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1]]},"article-number":"1756284819853208"}}