{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T15:39:18Z","timestamp":1775576358801,"version":"3.50.1"},"reference-count":27,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["CLRPG3D0044"],"award-info":[{"award-number":["CLRPG3D0044"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["CMRPG3F0551"],"award-info":[{"award-number":["CMRPG3F0551"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["CMRPG3F0552"],"award-info":[{"award-number":["CMRPG3F0552"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["CMRPG3H0031"],"award-info":[{"award-number":["CMRPG3H0031"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Dexlansoprazole has been shown to be efficacious for the treatment of gastroesophageal reflux disease. However, there is a paucity of data about its efficacy for Helicobacter pylori eradication. The aim of this study was to evaluate the efficacy of dexlansoprazole for H. pylori eradication as triple therapy in real-world practice. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Adult patients with endoscopically proven H. pylori related peptic ulcer diseases or gastritis were recruited for this study. The eradication status was assessed based on the results of the <jats:sup>13<\/jats:sup>C-urea breath test performed 4\u2009weeks after treatment. According to the different treatment regimens, the patients were allocated to group A: Esomeprazole 40\u2009mg b.i.d.\u2009+\u2009amoxicillin 1\u2009g b.i.d.\u2009+\u2009clarithromycin 500\u2009mg b.i.d. for 7\u2009days; group B: Esomeprazole 40\u2009mg q.d.\u2009+\u2009amoxicillin 1\u2009g b.i.d.\u2009+\u2009clarithromycin 500\u2009mg b.i.d. for 7\u2009days, or group C: Dexlansoprazole 60\u2009mg q.d.\u2009+\u2009amoxicillin 1\u2009g b.i.d.\u2009+\u2009clarithromycin 500\u2009mg b.i.d. for 7\u2009days. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> A total of 215 patients (49% males) were enrolled in this study, with a mean age of 55\u2009years. The eradication rates in group A, B, and C were 94.7% (71\/75), 89.6% (69\/77), and 93.7% (59\/63) ( p = 0.457), respectively. The adverse events were similar between the three groups ( p\u2009=\u20090.068). <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions:<\/jats:title><jats:p> This study suggests that dexlansoprazole-based triple therapy has an acceptable eradication rate for H. pylori infection. <\/jats:p><\/jats:sec>","DOI":"10.1177\/1756284819870960","type":"journal-article","created":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T05:14:26Z","timestamp":1567746866000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Efficacy of dexlansoprazole-based triple therapy for <i>Helicobacter pylori<\/i> infections"],"prefix":"10.1177","volume":"12","author":[{"given":"Chia-Jung","family":"Kuo","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou"},{"name":"Chang Gung University, College of Medicine, Taoyuan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9438-0398","authenticated-orcid":false,"given":"Chun-Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puo-Hsien","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Te","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Chang Gung Memorial Hospital, Linkou"},{"name":"Chang Gung University, College of Medicine, Taoyuan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Yu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao-Tsai","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou"},{"name":"Chang Gung University, College of Medicine, Taoyuan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Yao","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou"},{"name":"Chang Gung University, College of Medicine, Taoyuan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Jung","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou"},{"name":"Chang Gung University, College of Medicine, Taoyuan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Tang","family":"Chiu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, No. 5, Fuxing Street, Guishan Dist., Taoyuan City"},{"name":"Chang Gung University, College of Medicine, Taoyuan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2019,9,5]]},"reference":[{"key":"bibr1-1756284819870960","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12522"},{"key":"bibr2-1756284819870960","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60938-7"},{"key":"bibr3-1756284819870960","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312288"},{"key":"bibr4-1756284819870960","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i18.5283"},{"key":"bibr5-1756284819870960","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.6.1387"},{"key":"bibr6-1756284819870960","doi-asserted-by":"publisher","DOI":"10.1007\/BF01964416"},{"key":"bibr7-1756284819870960","first-page":"1314","volume":"57","author":"Furuta T","year":"2010","journal-title":"H. pylori. 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