{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T06:59:28Z","timestamp":1760597968420,"version":"3.41.2"},"reference-count":25,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p> Patient perception of colonoscopy varies greatly. Young slender women and patients with irritable bowel syndrome (IBS) appear to be at risk for periprocedural pain. Recent evidence suggests a high prevalence of joint hypermobility related connective tissue disorders in this population. Therefore, we aimed to investigate whether hypermobility spectrum disorder (HSD) is associated with increased pain during colonoscopy. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> We prospectively included patients undergoing routine colonoscopy. Subjects were assessed for HSD using the 2017 criteria, and IBS and functional dyspepsia using the Rome III criteria. After colonoscopy and recovery from sedation, patients were asked to report pain scores on a 100-mm visual analogue scale (VAS). In addition, caecal intubation time was measured, endoscopists scored the difficulty of the procedure (100-mm VAS) and procedure-related adverse events were registered. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> Of 200 included patients, 22 (11%) met criteria for HSD. A female predominance was observed in patients with HSD (86.4% versus 49.4%, p\u2009&lt;\u20090.001). A crude linear regression model demonstrated that pain scores were 13.30 mm higher in patients with HSD versus non-HSD patients (95% CI 0.07 \u2013 26.53, p\u2009=\u20090.049). When subsequently correcting for possible confounding factors, however, this difference in pain scores could be explained by a confounding effect of female gender. Caecal intubation time, perceived procedural difficulty and complication rate did not differ significantly between groups. <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> HSD does not seem to be a predictor of painful colonoscopy, probably due to female gender as a confounding factor. In addition, performing colonoscopy is not more complicated in patients with HSD versus non-HSD patients, nor is it associated with more adverse events. <\/jats:p><\/jats:sec>","DOI":"10.1177\/1756284820927310","type":"journal-article","created":{"date-parts":[[2020,7,17]],"date-time":"2020-07-17T11:58:03Z","timestamp":1594987083000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":4,"title":["Colonoscopy is safe and not associated with higher pain scores in patients with hypermobility spectrum disorder: results from an exploratory prospective study"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9532-2576","authenticated-orcid":false,"given":"Abraham B.","family":"Beckers","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Maastricht University Medical Center, Maastricht, Limburg, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Vork","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Maastricht University Medical Center, Maastricht, Limburg, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asma","family":"Fikree","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, Royal London Hospital, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rogier","family":"de Ridder","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Maastricht University Medical Center, Maastricht, Limburg, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qasim","family":"Aziz","sequence":"additional","affiliation":[{"name":"Wingate Institute of Neurogastroenterology, Queen Mary University of London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ad","family":"Masclee","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Maastricht University Medical Center, Maastricht, Limburg, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Keszthelyi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Gastroenterology-Hepatology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, PO box 5800, Maastricht, Limburg 6202 AZ, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2020,7,17]]},"reference":[{"key":"bibr1-1756284820927310","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4966"},{"key":"bibr2-1756284820927310","doi-asserted-by":"publisher","DOI":"10.1002\/0471221929"},{"key":"bibr3-1756284820927310","doi-asserted-by":"publisher","DOI":"10.1136\/gut.10.12.1004"},{"key":"bibr4-1756284820927310","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197904123001520"},{"key":"bibr5-1756284820927310","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003093421001"},{"key":"bibr6-1756284820927310","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2007.09.013"},{"key":"bibr7-1756284820927310","doi-asserted-by":"publisher","DOI":"10.1186\/1752-1947-5-229"},{"key":"bibr8-1756284820927310","doi-asserted-by":"publisher","DOI":"10.4253\/wjge.v5.i8.398"},{"key":"bibr9-1756284820927310","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000000189"},{"key":"bibr10-1756284820927310","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.12535"},{"key":"bibr11-1756284820927310","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.13013"},{"key":"bibr12-1756284820927310","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e328361dcd3"},{"key":"bibr13-1756284820927310","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31539"},{"key":"bibr14-1756284820927310","first-page":"804","volume":"34","author":"Remvig L","year":"2007","journal-title":"J Rheumatol"},{"key":"bibr15-1756284820927310","unstructured":"Drossman DA, Corazziari E, Delvaux M, et al. Rome III: the functional gastrointestinal disorders. 3rd ed. McLean (VA): Degnon Associates, 2006."},{"key":"bibr16-1756284820927310","unstructured":"Programme NCS. Quality assurance guidelines for colonoscopy, publication no. 6, http:\/\/www.cancerscreening.nhs.uk\/bowel\/publications\/nhsbcsp06.pdf (2011, accessed 12 March 2012)."},{"key":"bibr17-1756284820927310","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2008.05.057."},{"key":"bibr18-1756284820927310","doi-asserted-by":"publisher","DOI":"10.1111\/den.12323"},{"key":"bibr19-1756284820927310","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.429"},{"key":"bibr20-1756284820927310","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.01.014"},{"key":"bibr21-1756284820927310","first-page":"42","volume":"28","author":"Templeton GF","year":"2011","journal-title":"Commun Assoc Inf Syst"},{"key":"bibr22-1756284820927310","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90373-9"},{"key":"bibr23-1756284820927310","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.01.005"},{"key":"bibr24-1756284820927310","doi-asserted-by":"publisher","DOI":"10.1113\/JP277195"},{"key":"bibr25-1756284820927310","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1093\/rheumatology\/ker140","volume":"50","author":"Remvig L","year":"2011","journal-title":"Rheumatology (Oxford)"}],"container-title":["Therapeutic Advances in Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1756284820927310","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/1756284820927310","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/1756284820927310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T19:25:17Z","timestamp":1740857117000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/1756284820927310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":25,"alternative-id":["10.1177\/1756284820927310"],"URL":"https:\/\/doi.org\/10.1177\/1756284820927310","relation":{},"ISSN":["1756-2848","1756-2848"],"issn-type":[{"type":"print","value":"1756-2848"},{"type":"electronic","value":"1756-2848"}],"subject":[],"published":{"date-parts":[[2020,1]]},"article-number":"1756284820927310"}}