{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T11:23:48Z","timestamp":1781349828541,"version":"3.54.1"},"reference-count":28,"publisher":"SAGE Publications","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Therap Adv Gastroenterol"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec><jats:title>Background and aim:<\/jats:title><jats:p> Many female inflammatory bowel disease (IBD) patients report symptoms exacerbation before and during menses. Our aim was to characterize their symptoms and specific risk factors in comparison with healthy controls. <\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p> Female IBD patients aged 18\u201350\u2009years were asked to fill out a questionnaire recording their demographic and disease characteristics, menstruation history and symptoms. Disease activity was defined by Harvey\u2013Bradshaw index (HBI) for Crohn\u2019s disease (CD) patients and modified mayo score for ulcerative colitis (UC) patients. Healthcare providers answering an internet survey assessing bowel symptoms during menstruation served as healthy controls. <\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p> A total of 139 IBD patients, of whom 100 were CD patients, filled the questionnaire. The mean age was 30.4 [\u00b17.7 standard deviation (SD)], mean disease duration was 7.8 (\u00b16 SD), mean HBI was 4.7 (\u00b13.8 SD), and mean Mayo score was 2.1 (\u00b12.5 SD). A change in bowel habits during menstruation was reported by 72% of CD patients compared with 56% of UC patients ( p\u2009=\u20090.07). Out of 258 healthy controls, 93% reported a change in bowel habits during menstruation compared with 68% of IBD patients ( p\u2009&lt;\u20090.001). However, other abdominal and constitutional symptoms were significantly more prevalent among IBD patients compared with healthy controls ( p\u2009&lt;\u20090.01 for most parameters). Smoking status, biologic treatment, and previous abdominal operation were found to significantly aggravate symptoms during menses in IBD patients <\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p> IBD patients experience various symptoms during menses significantly more commonly than healthy women. Smoking, biologic treatment, and previous abdominal operations are risk factors for higher symptomatic burden. Following future validation and research, these results can help in patients\u2019 risk stratification and possibly in risk reduction. <\/jats:p><\/jats:sec>","DOI":"10.1177\/1756284820929806","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T04:21:24Z","timestamp":1591849284000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Change in bowel habits during menstruation: are IBD patients different?"],"prefix":"10.1177","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1513-7280","authenticated-orcid":false,"given":"Adi","family":"Lahat","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alona","family":"Falach-Malik","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Sheba Medical Center, Tel Hashomer, Israel, affiliated with Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"Haj","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Sheba Medical Center, Tel Hashomer, Israel, affiliated with Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zina","family":"shatz","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Sheba Medical Center, Tel Hashomer, Israel, affiliated with Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shomron","family":"Ben- Horin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Sheba Medical Center, Tel Hashomer, Israel, affiliated with Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2020,6,10]]},"reference":[{"key":"bibr1-1756284820929806","doi-asserted-by":"publisher","DOI":"10.1080\/07399338809515818"},{"key":"bibr2-1756284820929806","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(81)90263-8"},{"key":"bibr3-1756284820929806","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2013.7.1.51"},{"key":"bibr4-1756284820929806","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.540_i.x"},{"key":"bibr5-1756284820929806","first-page":"95","volume":"108","author":"Guzelant G","year":"2017","journal-title":"Clin Exp Rheumatol"},{"key":"bibr6-1756284820929806","first-page":"250","volume":"13","author":"Parlak 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